Remdesivir

Catalog No. A17170

Remdesivir也称为GS-5734，在治疗24小时后，其EC50为30 nM抑制鼠肝炎病毒（MHV），并在HAE细胞中以两个74 nM的EC50阻断HAS细胞中的SARS-CoV和MERS-CoV。

Product Citations

Haidar Saify Nabiabad, .et al. Specific delivering of RNAi using Spike's aptamer-functionalized lipid nanoparticles for targeting SARS-CoV-2: A strong anti-Covid drug in a clinical case study, Chem Biol Drug Des, 2022, Feb;99(2):233-246 PMID: 34714580
Kuoyuan Cheng, .et al. Genome-scale metabolic modeling reveals SARS-CoV-2-induced host metabolic reprogramming and identifies metabolic antiviral targets, bioRxiv, 2021, Jan 28 PMID: 33532779

Technical details

Catalog Num	A17170
M. Wt	602.58
Formula	C27H35N6O8P
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1809249-37-3
Synonyms	GS-5734, GS 5734, GS5734
SMILES	CCC(CC)COC([C@H](C)N[P@](OC[C@H]1O[C@](C2=CC=C3N2N=CC=C3N)(C#N)[C@H](O)[C@@H]1O)(OC4=CC=CC=C4)=O)=O

Biological Activity

Remdesivir也称为GS-5734，在治疗24小时后，其EC50为30 nM抑制鼠肝炎病毒（MHV），并在HAE细胞中以两个74 nM的EC50阻断HAS细胞中的SARS-CoV和MERS-CoV。

Solubility *

In vitro	DMSO	96 mg/mL (159.31 mM)
	Water	Insoluble
	Ethanol	15 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.6 mL	82.98 mL	165.95 mL
0.5 mM	3.32 mL	16.6 mL	33.19 mL
1 mM	1.66 mL	8.3 mL	16.6 mL
5 mM	0.33 mL	1.66 mL	3.32 mL

*The above data is based on the productmolecular weight 602.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.