MRTX1257

Catalog No. A17223

MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.

Technical details

Catalog Num	A17223
M. Wt	565.722
Formula	C33H39N7O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2206736-04-9
Synonyms	MRTX-1257; MRTX 1257;
SMILES	N#CC[C@@H]1N(C(C=C)=O)CCN(C2=C3C(CN(C4=C5C(C)=CC=CC5=CC=C4)CC3)=NC(OC[C@H]6N(C)CCC6)=N2)C1

Biological Activity

MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.

Solubility *

In vitro	DMSO	89 mg/mL (157.32 mM)
	Water	Insoluble
	Ethanol	27 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.68 mL	88.38 mL	176.77 mL
0.5 mM	3.54 mL	17.68 mL	35.35 mL
1 mM	1.77 mL	8.84 mL	17.68 mL
5 mM	0.35 mL	1.77 mL	3.54 mL

*The above data is based on the productmolecular weight 565.722. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

MRTX1257

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions