Losartan

Catalog No. A17510

Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

Technical details

Catalog Num	A17510
M. Wt	422.91
Formula	C22H23ClN6O
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	114798-26-4
Synonyms	Losartan; DUP 89; DUP-89; DUP89;
SMILES	OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2

Biological Activity

Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

Solubility *

In vitro	DMSO	76 mg/mL (179.7 mM)
	Water
	Ethanol
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.65 mL	118.23 mL	236.46 mL
0.5 mM	4.73 mL	23.65 mL	47.29 mL
1 mM	2.36 mL	11.82 mL	23.65 mL
5 mM	0.47 mL	2.36 mL	4.73 mL

*The above data is based on the productmolecular weight 422.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Losartan

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions