Doxazosin

Catalog No. A17779

Doxazosin is an α-1 adrenergic receptor blocker that inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. Blockages of the alpha-1 adrenergic action on the vascular smooth muscles lead to a decrease in vascular resistance and antihypertensive activity.

Technical details

Catalog Num	A17779
M. Wt	451.48
Formula	C23H25N5O5
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	74191-85-8
Synonyms	Doxazosin; Cardura; 74191-85-8; Doxazosinum; Doxazosina; Doxazosine; Alfamedin; Aliud Brand of Doxazosin Mesylate; Almirall Brand of Doxazosin Mesylate; Alpharma Brand of Doxazosin Mesylate; Alter Brand of Doxazosin Mesylate; Apo Doxazosin; Apo-Doxazosin;
SMILES	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC

Biological Activity

Solubility *

In vitro	DMSO	29 mg/mL (64.23 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.15 mL	110.75 mL	221.49 mL
0.5 mM	4.43 mL	22.15 mL	44.3 mL
1 mM	2.21 mL	11.07 mL	22.15 mL
5 mM	0.44 mL	2.21 mL	4.43 mL

*The above data is based on the productmolecular weight 451.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Doxazosin

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions