Icatibant

Catalog No. A18074

Icatibant (HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

Technical details

Catalog Num	A18074
M. Wt	1304.52
Formula	C59H89N19O13S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	130308-48-4
Synonyms	Firazyr
SMILES	N=C(N)NC(C(C1NCC2=C(C=CC=C2)C1)=O)CC[C@@H](C(O)=O)N(C([C@H](CO)N(C(CN(C([C@H]3N(C([C@H](CCCNC(N)=N)NC([C@@H](CCCNC(N)=N)N)=O)=O)CCC3)=O)C(C4NC[C@H](O)C4)=O)=O)C([C@H](CC5=CC=CS5)N)=O)=O)C(C6N[C@@]7([H])CCCC[C@@]7([H])C6)=O

Biological Activity

Icatibant (HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	7.67 mL	38.33 mL	76.66 mL
0.5 mM	1.53 mL	7.67 mL	15.33 mL
1 mM	0.77 mL	3.83 mL	7.67 mL
5 mM	0.15 mL	0.77 mL	1.53 mL

*The above data is based on the productmolecular weight 1304.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Icatibant

Technical details

Biological Activity

Preparing Stock Solutions