ZXH-3-26

Catalog No. A18399

ZXH-3-26 is a selective PROTAC BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM.

Technical details

Catalog Num	A18399
M. Wt	785.27
Formula	C38H37ClN8O7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2243076-67-5
Synonyms	ZXH326, ZXH-326
SMILES	O=C(OC)C[C@H]1C2=NN=C(C)N2C3=C(C(C)=C(C(NCCCCCNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O)=O)S3)C(C7=CC=C(Cl)C=C7)=N1

Biological Activity

ZXH-3-26 is a selective PROTAC BRD4 degrader with a DC50/5h (DC50/5h referring to half-maximal degradation after 5 hours of treatment) of ~ 5 nM.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.73 mL	63.67 mL	127.34 mL
0.5 mM	2.55 mL	12.73 mL	25.47 mL
1 mM	1.27 mL	6.37 mL	12.73 mL
5 mM	0.25 mL	1.27 mL	2.55 mL

*The above data is based on the productmolecular weight 785.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

ZXH-3-26

Technical details

Biological Activity

Preparing Stock Solutions