A1874

Catalog No. A18735

A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.

Technical details

Catalog Num	A18735
M. Wt	1173.6
Formula	C58H62Cl3F2N9O7S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2064292-12-0
Synonyms	A1874, A-1874
SMILES	O=C([C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C3=CC=CC(Cl)=C3F)NC4=CC=C(C(NCCOCCOCCOCCNC(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)=O)C=C4

Biological Activity

A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.

Solubility *

In vitro	DMSO	92 mg/mL (78.38 mM)
	Water	Insoluble
	Ethanol	92 mg/mL (78.38 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	8.52 mL	42.6 mL	85.21 mL
0.5 mM	1.7 mL	8.52 mL	17.04 mL
1 mM	0.85 mL	4.26 mL	8.52 mL
5 mM	0.17 mL	0.85 mL	1.7 mL

*The above data is based on the productmolecular weight 1173.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

A1874

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions