JAK3 covalent inhibitor-1
Catalog No. A18926
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs.
| Catalog Num | A18926 |
|---|---|
| M. Wt | 448.47 |
| Formula | C22H17FN6O2S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2300106-50-5 |
| Synonyms | 0 |
| SMILES | O=S(N[C@H](C[C@@H]1NC#N)C(C1=C2)=CC=C2C3=C4C(NC=C4)=NC=N3)(C5=CC=CC(F)=C5)=O |
JAK3 covalent inhibitor-1 is a potent and selective janus kinase 3 (JAK3) covalent inhibitor with an IC50 of 11 nM and shows 246-fold selectivity vs other JAKs.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.3 mL | 111.49 mL | 222.98 mL |
| 0.5 mM | 4.46 mL | 22.3 mL | 44.6 mL |
| 1 mM | 2.23 mL | 11.15 mL | 22.3 mL |
| 5 mM | 0.45 mL | 2.23 mL | 4.46 mL |
*The above data is based on the productmolecular weight 448.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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