RET-IN-1

Catalog No. A19015

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .

Technical details

Catalog Num	A19015
M. Wt	553.61
Formula	C29H31N9O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2222755-14-6
Synonyms
SMILES	N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[C@H]7CNCCO7)=CN2N=C1

Biological Activity

RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively .

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.06 mL	90.32 mL	180.63 mL
0.5 mM	3.61 mL	18.06 mL	36.13 mL
1 mM	1.81 mL	9.03 mL	18.06 mL
5 mM	0.36 mL	1.81 mL	3.61 mL

*The above data is based on the productmolecular weight 553.61. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

RET-IN-1

Technical details

Biological Activity

Preparing Stock Solutions