Tyk2-IN-8

Catalog No. A19052

Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis.

Technical details

Catalog Num	A19052
M. Wt	383.41
Formula	C20H17N9
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2127109-84-4
Synonyms
SMILES	N#CC[C@@]1(N2N=CC(C3=NC(C4=CN(C)N=C4)=CN5C3=CC=N5)=C2)C[C@H](C#N)C1

Biological Activity

Tyk2-IN-8 (compound 10) is a selective TYK2 inhibitor, which binds to TYK2 catalytically active JH1 domain with an IC50 of 17 nM, used in the treatment of psoriasis.

Solubility *

In vitro	DMSO	72 mg/mL (187.78 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.08 mL	130.41 mL	260.82 mL
0.5 mM	5.22 mL	26.08 mL	52.16 mL
1 mM	2.61 mL	13.04 mL	26.08 mL
5 mM	0.52 mL	2.61 mL	5.22 mL

*The above data is based on the productmolecular weight 383.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Tyk2-IN-8

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions