AAPK-25

Catalog No. A19085

AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis.
Catalog Num A19085
M. Wt 442.32
Formula C21H13Cl2N3O2S
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 2247919-28-2
Synonyms AAPK 25, AAPK25
SMILES ClC1=CC(C(NC2=CC=C(C=C(C(NC3=NC=CS3)=O)C=C4)C4=C2)=O)=CC=C1Cl
AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.61 mL 113.04 mL 226.08 mL
0.5 mM 4.52 mL 22.61 mL 45.22 mL
1 mM 2.26 mL 11.3 mL 22.61 mL
5 mM 0.45 mL 2.26 mL 4.52 mL

*The above data is based on the productmolecular weight 442.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.