THAL-SNS-032

Catalog No. A19088

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

Technical details

Catalog Num	A19088
M. Wt	869.02
Formula	C40H52N8O10S2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2139287-33-3
Synonyms
SMILES	O=C(NCCOCCOCCOCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CN4CCC(C(NC5=NC=C(SCC6=NC=C(C(C)(C)C)O6)S5)=O)CC4

Biological Activity

THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN).

Solubility *

In vitro	DMSO	89 mg/mL (102.41 mM)
	Water	Insoluble
	Ethanol	27 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.51 mL	57.54 mL	115.07 mL
0.5 mM	2.3 mL	11.51 mL	23.01 mL
1 mM	1.15 mL	5.75 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL

*The above data is based on the productmolecular weight 869.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

THAL-SNS-032

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions