dBET57

Catalog No. A19133

dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology.

Technical details

Catalog Num	A19133
M. Wt	699.18
Formula	C34H31ClN8O5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1883863-52-2
Synonyms	dBET 57, dBET-57
SMILES	O=C(NCCNC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4

Biological Activity

dBET57 is a potent and selective degrader of BRD4BD1 based on the PROTAC technology.

Solubility *

In vitro	DMSO	89 mg/mL (127.29 mM)
	Water	Insoluble
	Ethanol	11 mg/mL (15.73 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.3 mL	71.51 mL	143.02 mL
0.5 mM	2.86 mL	14.3 mL	28.6 mL
1 mM	1.43 mL	7.15 mL	14.3 mL
5 mM	0.29 mL	1.43 mL	2.86 mL

*The above data is based on the productmolecular weight 699.18. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

dBET57

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions