Gefapixant
Catalog No. A19254
Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
| Catalog Num | A19254 |
|---|---|
| M. Wt | 353.4 |
| Formula | C14H19N5O4S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1015787-98-0 |
| Synonyms | AF219, AF 219, AF-219; MK-7264, MK7264, MK 7264 |
| SMILES | O=S(C1=CC(OC2=CN=C(N)N=C2N)=C(C(C)C)C=C1OC)(N)=O |
Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
| In vitro | DMSO | 65 mg/mL (183.92 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.3 mL | 141.48 mL | 282.97 mL |
| 0.5 mM | 5.66 mL | 28.3 mL | 56.59 mL |
| 1 mM | 2.83 mL | 14.15 mL | 28.3 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
*The above data is based on the productmolecular weight 353.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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