GSK5182

Catalog No. A19383

GSK5182 is a highly selective inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM and does not interact with other nuclear receptors, including ERRα or ERα.

Product Citations

Sen He, .et al. The potential endocrine disruption mechanism of anthelmintic drug niclosamide by activating estrogen receptors and estrogen-related receptors, Toxicology, 2021, May 4;457:152805 PMID: 33961950

Technical details

Catalog Num	A19383
M. Wt	417.54
Formula	C27H31NO3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	877387-37-6
Synonyms	GSK 5182, GSK-5182
SMILES	OCCC/C(C1=CC=CC=C1)=C(C2=CC=C(O)C=C2)/C3=CC=C(OCCN(C)C)C=C3

Biological Activity

GSK5182 is a highly selective inverse agonist of estrogen-related receptor γ (ERRγ) with an IC50 of 79 nM and does not interact with other nuclear receptors, including ERRα or ERα.

Solubility *

In vitro	DMSO	78 mg/mL
	Water	Insoluble
	Ethanol	78 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.95 mL	119.75 mL	239.5 mL
0.5 mM	4.79 mL	23.95 mL	47.9 mL
1 mM	2.39 mL	11.97 mL	23.95 mL
5 mM	0.48 mL	2.39 mL	4.79 mL

*The above data is based on the productmolecular weight 417.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.