GSK3145095

Catalog No. A19427

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .

Technical details

Catalog Num	A19427
M. Wt	397.38
Formula	C20H17F2N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1622849-43-7
Synonyms	GSK-3145095; GSK 3145095
SMILES	FC1=CC(F)=CC2=C1NC([C@@H](NC(C3=NNC(CC4=CC=CC=C4)=N3)=O)CC2)=O

Biological Activity

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM .

Solubility *

In vitro	DMSO	74 mg/mL (186.22 mM)
	Water	Insoluble
	Ethanol	6 mg/mL (15.09 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.16 mL	125.82 mL	251.65 mL
0.5 mM	5.03 mL	25.16 mL	50.33 mL
1 mM	2.52 mL	12.58 mL	25.16 mL
5 mM	0.5 mL	2.52 mL	5.03 mL

*The above data is based on the productmolecular weight 397.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

GSK3145095

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions