Poseltinib (HM71224, LY3337641)
Catalog No. A19450
Poseltinib, an orally active, selective and irreversible Bruton??s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively.
| Catalog Num | A19450 |
|---|---|
| M. Wt | 470.52 |
| Formula | C26H26N6O3 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1353552-97-2 |
| Synonyms | HM 71224, HM-71224, LY-333764, LY 33376411 |
| SMILES | O=C(C=C)NC1=CC=CC(OC2=C(OC=C3)C3=NC(NC4=CC=C(N5CCN(C)CC5)C=C4)=N2)=C1 |
Poseltinib, an orally active, selective and irreversible Bruton??s tyrosine kinase (BTK) inhibitor (IC50 =1.95 nM), with 0.3, 2.3 and 2.4-fold selectivity for BTK over BMX, TEC and TXK, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.25 mL | 106.27 mL | 212.53 mL |
| 0.5 mM | 4.25 mL | 21.25 mL | 42.51 mL |
| 1 mM | 2.13 mL | 10.63 mL | 21.25 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.25 mL |
*The above data is based on the productmolecular weight 470.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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