Asciminib

Catalog No. A19658

Asciminib (ABL001) is a potent and selective allosteric Bcr-Abl inhibitor; inhibits Ba/F3 cells grown with an IC50 of 0.25 nM.

Technical details

Catalog Num	A19658
M. Wt	449.84
Formula	C20H18ClF2N5O3
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1492952-76-7
Synonyms	ABL001, ABL 001, ABL-001
SMILES	O=C(C1=CC(C2=NNC=C2)=C(N3C[C@H](O)CC3)N=C1)NC4=CC=C(OC(F)(Cl)F)C=C4

Biological Activity

Asciminib (ABL001) is a potent and selective allosteric Bcr-Abl inhibitor; inhibits Ba/F3 cells grown with an IC50 of 0.25 nM.

Solubility *

In vitro	DMSO	76 mg/mL (168.94 mM)
	Water
	Ethanol	76 mg/mL (168.94 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.23 mL	111.15 mL	222.3 mL
0.5 mM	4.45 mL	22.23 mL	44.46 mL
1 mM	2.22 mL	11.12 mL	22.23 mL
5 mM	0.44 mL	2.22 mL	4.45 mL

*The above data is based on the productmolecular weight 449.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Asciminib

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions