Elexacaftor

Catalog No. A20094

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR).

Technical details

Catalog Num	A20094
M. Wt	597.65
Formula	C26H34F3N7O4S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	2216712-66-0
Synonyms	VX-445, VX445??
SMILES	CC1(C)C[C@H](C)CN1C2=C(C(NS(C3=CN(C)N=C3C)(=O)=O)=O)C=CC(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)=N2

Biological Activity

Elexacaftor (VX-445, Compound 1) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR).

Solubility *

In vitro	DMSO	99 mg/mL (165.65 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.73 mL	83.66 mL	167.32 mL
0.5 mM	3.35 mL	16.73 mL	33.46 mL
1 mM	1.67 mL	8.37 mL	16.73 mL
5 mM	0.33 mL	1.67 mL	3.35 mL

*The above data is based on the productmolecular weight 597.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

Elexacaftor

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions