TAK-243
Catalog No. A20369
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination.
| Catalog Num | A20369 |
|---|---|
| M. Wt | 519.52 |
| Formula | C19H20F3N5O5S2 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1450833-55-2 |
| Synonyms | TAK 243, TAK243, MLN7243, MLN 7243, MLN-7243 |
| SMILES | O=S(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](NC2=CC=NC3=CC(C4=CC=CC(SC(F)(F)F)=C4)=NN23)C1)(N)=O |
TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination.
| In vitro | DMSO | 85 mg/mL (163.61 mM) | |
| Water | Insoluble | ||
| Ethanol | 21 mg/mL (40.42 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.25 mL | 96.24 mL | 192.49 mL |
| 0.5 mM | 3.85 mL | 19.25 mL | 38.5 mL |
| 1 mM | 1.92 mL | 9.62 mL | 19.25 mL |
| 5 mM | 0.38 mL | 1.92 mL | 3.85 mL |
*The above data is based on the productmolecular weight 519.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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