SF2523

Catalog No. A20557

SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.

Product Citations

Virender Kumar, .et al. Polymeric nanomedicine for overcoming resistance mechanisms in hedgehog and Myc-amplified medulloblastoma, Biomaterials, 2021, Nov;278:121138 PMID: 34634662

Technical details

Catalog Num	A20557
M. Wt	371.41
Formula	C19H17NO5S
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1174428-47-7
Synonyms	SF 2523, SF-2523
SMILES	O=C1C=C(N2CCOCC2)OC3=C1SC=C3C4=CC=C(OCCO5)C5=C4

Biological Activity

SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.

Solubility *

In vitro	DMSO	29 mg/mL (78.08 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (18.84 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.92 mL	134.62 mL	269.24 mL
0.5 mM	5.38 mL	26.92 mL	53.85 mL
1 mM	2.69 mL	13.46 mL	26.92 mL
5 mM	0.54 mL	2.69 mL	5.38 mL

*The above data is based on the productmolecular weight 371.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.