MC-Val-Cit-PAB

Catalog No. A20571

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.

Technical details

Catalog Num	A20571
M. Wt	572.65
Formula	C28H40N6O7
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	159857-80-4
Synonyms
SMILES	CC(C)[C@@H](C(N[C@@H](CCCNC(N)=O)C(NC1=CC=C(CO)C=C1)=O)=O)NC(CCCCCN2C(C=CC2=O)=O)=O

Biological Activity

MC-Val-Cit-PAB is a cathepsin cleavable ADC linker that is used for making antibody-drug conjugate. FDA approved drugs such as brentuximab vedotin use this linker.

Solubility *

In vitro	DMSO	98 mg/mL (171.13 mM)
	Water
	Ethanol
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.46 mL	87.31 mL	174.63 mL
0.5 mM	3.49 mL	17.46 mL	34.93 mL
1 mM	1.75 mL	8.73 mL	17.46 mL
5 mM	0.35 mL	1.75 mL	3.49 mL

*The above data is based on the productmolecular weight 572.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

MC-Val-Cit-PAB

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions