SPDP
Catalog No. A20578
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
| Catalog Num | A20578 |
|---|---|
| M. Wt | 312.36 |
| Formula | C12H12N2O4S2 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 68181-17-9 |
| Synonyms | SPDP Crosslinker |
| SMILES | O=C(ON1C(CCC1=O)=O)CCSSC2=NC=CC=C2 |
SPDP (SPDP Crosslinker) is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls. It is a glutathione cleavable ADC linker used for the antibody-drug conjugates (ADCs).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 32.01 mL | 160.07 mL | 320.14 mL |
| 0.5 mM | 6.4 mL | 32.01 mL | 64.03 mL |
| 1 mM | 3.2 mL | 16.01 mL | 32.01 mL |
| 5 mM | 0.64 mL | 3.2 mL | 6.4 mL |
*The above data is based on the productmolecular weight 312.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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