SAR405

Catalog No. A21345

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).

Technical details

Catalog Num	A21345
M. Wt	443.85
Formula	C19H21ClF3N5O2
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1523406-39-4
Synonyms	SAR 405, SAR-405
SMILES	O=C1N(C2=NC(N3[C@H](C)COCC3)=C1)CC[C@@H](C(F)(F)F)N2CC4=CC(Cl)=CN=C4

Biological Activity

SAR405 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM).

Solubility *

In vitro (25°C)	DMSO	Warmed: 76 mg/mL (171.22 mM)
	Water	Insoluble
	Ethanol	76 mg/mL (171.22 mM)
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	3 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.53 mL	112.65 mL	225.3 mL
0.5 mM	4.51 mL	22.53 mL	45.06 mL
1 mM	2.25 mL	11.27 mL	22.53 mL
5 mM	0.45 mL	2.25 mL	4.51 mL

*The above data is based on the productmolecular weight 443.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Adooq Bioscience

SAR405

Technical details

Biological Activity

Solubility *

Preparing Stock Solutions