NVP-BSK805 dihydrochloride
Catalog No. A21406
NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
| Catalog Num | A21406 |
|---|---|
| M. Wt | 563.47 |
| Formula | C27H30Cl2F2N6O |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1942919-79-0 |
| Synonyms | BSK805 dihydrochloride, BSK 805, BSK-805 |
| SMILES | FC1=C(CN2CCOCC2)C(F)=CC(C3=C4N=C(C5=CN(C6CCNCC6)N=C5)C=NC4=CC=C3)=C1.Cl.Cl |
NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
| In vitro (25°C) | DMSO | 104 mg/mL (184.57 mM) | |
| Water | 3 mg/mL (5.32 mM) | ||
| Ethanol | 14 mg/mL (24.85 mM) | ||
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.75 mL | 88.74 mL | 177.47 mL |
| 0.5 mM | 3.55 mL | 17.75 mL | 35.49 mL |
| 1 mM | 1.77 mL | 8.87 mL | 17.75 mL |
| 5 mM | 0.35 mL | 1.77 mL | 3.55 mL |
*The above data is based on the productmolecular weight 563.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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