Trametinib (DMSO solvate)
Catalog No. A21450
Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.
- Yuki Shimizu, .et al. Acquired resistance to BRAF inhibitors is mediated by BRAF splicing variants in BRAF V600E mutation-positive colorectal neuroendocrine carcinoma, Cancer Lett, 2022, Sep 1;543 PMID: 35724767
| Catalog Num | A21450 |
|---|---|
| M. Wt | 693.53 |
| Formula | C28H29FIN5O5S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1187431-43-1 |
| Synonyms | GSK-1120212 (DMSO solvate), GSK1120212, GSK 1120212; JTP-74057 (DMSO solvate), JTP74057, JTP 74057 |
| SMILES | CN1C(C(C)=C(N(C(N(C2=O)C3CC3)=O)C4=CC=CC(NC(C)=O)=C4)C2=C1NC5=CC=C(C=C5F)I)=O.CS(C)=O |
Trametinib DMSO solvate (GSK-1120212 (DMSO solvate);JTP-74057 (DMSO solvate)) is a potent MEK inhibitor that specifically inhibits MEK1/2, with an IC50 value of about 2 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.42 mL | 72.09 mL | 144.19 mL |
| 0.5 mM | 2.88 mL | 14.42 mL | 28.84 mL |
| 1 mM | 1.44 mL | 7.21 mL | 14.42 mL |
| 5 mM | 0.29 mL | 1.44 mL | 2.88 mL |
*The above data is based on the productmolecular weight 693.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Contact information
United StatesAdooq Bioscience
Toll Free: (866) 930-6790
Fax: +1-323-606-8156
Email: sales@adooq.com
ADOOQ 产品质量保证
We promise all products to perform as described.