WS-383
Catalog No. A21483
WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2.
| Catalog Num | A21483 |
|---|---|
| M. Wt | 498.46 |
| Formula | C18H21Cl2N9S2 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 2247544-02-9 |
| Synonyms | WS383, WS 383 |
| SMILES | CN(C)CCN1N=NN=C1SC2=CC(C)=NC3=NC(SCC4=CC=C(Cl)C=C4)=NN23.Cl |
WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.06 mL | 100.31 mL | 200.62 mL |
| 0.5 mM | 4.01 mL | 20.06 mL | 40.12 mL |
| 1 mM | 2.01 mL | 10.03 mL | 20.06 mL |
| 5 mM | 0.4 mL | 2.01 mL | 4.01 mL |
*The above data is based on the productmolecular weight 498.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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