Ro 31-8220
Catalog No. A21765
Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.
| Catalog Num | A21765 |
|---|---|
| M. Wt | 457.55 |
| Formula | C25H23N5O2S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 125314-64-9 |
| Synonyms | Bisindolylmaleimide IX, Ro31-8220, Ro-31-8220 |
| SMILES | NC(SCCCN1C=C(C2=C(C3=CN(C)C4=C3C=CC=C4)C(NC2=O)=O)C5=C1C=CC=C5)=N |
Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.86 mL | 109.28 mL | 218.56 mL |
| 0.5 mM | 4.37 mL | 21.86 mL | 43.71 mL |
| 1 mM | 2.19 mL | 10.93 mL | 21.86 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.37 mL |
*The above data is based on the productmolecular weight 457.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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