RO6889678
Catalog No. A22490
RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 ?l/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 ?l/min per mg protein, respectively.
| Catalog Num | A22490 |
|---|---|
| M. Wt | 494.92 |
| Formula | C21H20ClFN4O5S |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1578153-27-1 |
| Synonyms | RO6889678, RO-6889678, RO 6889678 |
| SMILES | O=C([C@H]1N(CC2=C(C(OC)=O)[C@H](C3=CC=C(F)C=C3Cl)N=C(C4=NC=CS4)N2)CCOC1)O |
RO6889678 is an inhibitor of HBV with a complex ADME profile. RO6889678 showed an intracellular enrichment of 78-fold in hepatocytes, with an apparent intrinsic clearance of 5.2 ?l/min per mg protein and uptake and biliary clearances of 2.6 and 1.6 ?l/min per mg protein, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.21 mL | 101.03 mL | 202.05 mL |
| 0.5 mM | 4.04 mL | 20.21 mL | 40.41 mL |
| 1 mM | 2.02 mL | 10.1 mL | 20.21 mL |
| 5 mM | 0.4 mL | 2.02 mL | 4.04 mL |
*The above data is based on the productmolecular weight 494.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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