JNJ-10198409
Catalog No. A22554
JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively).
| Catalog Num | A22554 |
|---|---|
| M. Wt | 325.3434 |
| Formula | C18H16FN3O2 |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 627518-40-5 |
| Synonyms | JNJ-10198409, JNJ 10198409, JNJ10198409, RWJ-540973, RWJ 540973, RWJ540973. |
| SMILES | COC1=CC2=C(C=C1OC)CC3=C2NN=C3NC4=CC=CC(F)=C4 |
JNJ 10198409 is a potent platelet-derived growth factor receptor (PDGFR) inhibitor (IC50 values are 4.2 and 45 nM for PDGFRβ and PDGFRα, respectively). Also inhibits c-Abl, Lck, c-Src and Fyn kinases (IC50 values are 22, 100, 185 and 378 nM respectively).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 30.74 mL | 153.68 mL | 307.37 mL |
| 0.5 mM | 6.15 mL | 30.74 mL | 61.47 mL |
| 1 mM | 3.07 mL | 15.37 mL | 30.74 mL |
| 5 mM | 0.61 mL | 3.07 mL | 6.15 mL |
*The above data is based on the productmolecular weight 325.3434. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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