17-DMAG HCl (Alvespimycin)

目录号: A10011

Hsp90 inhibitor

17-DMAG HCl (Alvespimycin)

17-DMAG HCl (Alvespimycin) Chemical Structure

CAS NO. 467214-21-7

17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.

库存: 缺货

规格 价格
25 mg
¥ 1,000.00
50 mg
¥ 1,800.00
100 mg
¥ 2,700.00
200 mg
¥ 4,200.00
10mM * 1mL in DMSO
¥ 850.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

17-DMAG is a water-soluble analog of 17-AAG and geldanamycin that binds the ATP binding site of Hsp90 and inhibits its chaperone activity. Displays more potent antitumor activity than 17-AAG.
Targets
HSP90 (Cell-free assay)
62 nM
In vitro (25°C) DMSO 131 mg/mL (200.54 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.31 mL 76.55 mL 153.09 mL
0.5 mM 3.06 mL 15.31 mL 30.62 mL
1 mM 1.53 mL 7.65 mL 15.31 mL
5 mM 0.31 mL 1.53 mL 3.06 mL

*The above data is based on the productmolecular weight 653.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

目录号 A10011
MECHANISM OF ACTION Inhibitor
M. Wt 653.2
Formula C32H48N4O8.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 467214-21-7
Synonyms 17DMAG, NSC 707545
SMILES CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl

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