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17-DMAG HCl (Alvespimycin)

17-DMAG HCl (Alvespimycin)

Name: 17-DMAG HCl (Alvespimycin)
SKU: A10011

目录号: A10011

Hsp90 抑制剂

Product Citations (2)

17-DMAG HCl (Alvespimycin) Chemical Structure

CAS NO. 467214-21-7

17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物，与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。

库存：缺货

规格	价格
25 mg	￥ 1,000.00
50 mg	￥ 1,800.00
100 mg	￥ 2,700.00
200 mg	￥ 4,200.00
10mM * 1mL in DMSO	￥ 850.00

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产品详情

生物活性

17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物，与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。

靶点信息

HSP90 (Cell-free assay)
62 nM

溶解度 *

In vitro (25°C)	DMSO	127 mg/mL (194.42 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.31 mL	76.55 mL	153.09 mL
0.5 mM	3.06 mL	15.31 mL	30.62 mL
1 mM	1.53 mL	7.65 mL	15.31 mL
5 mM	0.31 mL	1.53 mL	3.06 mL

*The above data is based on the productmolecular weight 653.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10011
作用机制	Inhibitor (抑制剂)
M. Wt	653.2
Formula	C32H48N4O8.HCl
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	467214-21-7
Synonyms	17DMAG, NSC 707545
SMILES	CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl