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微信关注MAPK | MAPK 信号通路
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A10453 SALE |
Honokiol |
Antiangiogenic and Antitumor Agent |
Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines.
|
A14137 SALE |
SL-327 |
MKK/MEK 抑制剂 |
SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
|
A11264 |
Refametinib |
MEK 抑制剂 |
Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
|
A15050 |
Cobimetinib (racemate) |
MEK 抑制剂 |
Cobimetinib is a potent, highly selective inhibitor of MEK1/2.
|
A15051 |
Cobimetinib (R-enantiomer) |
MEK 抑制剂 |
Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).
|
A15157 |
MEK inhibitor |
MEK 抑制剂 |
MEK inhibitor is a potent MEK inhibitor, antitumor agent.
|
A15762 |
BI-847325
|
MEK/Aurora 抑制剂 |
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
|
A14380 |
G-479 |
MEK 抑制剂 |
G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects.
|
A12974 |
GDC-0623 |
MEK1 抑制剂 |
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
|
A16032 |
PD 198306 |
MEK 抑制剂 |
PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor.
|
A16044 |
PD 334581 |
MEK1 抑制剂 |
PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1.
|
A10256 SALE |
PD0325901 |
MEK 抑制剂 |
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
|
A10257 |
AZD6244 (Selumetinib) |
MEK 抑制剂 |
AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
|
A10705 |
PD98059 |
MEK 抑制剂 |
PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
|
A10212 SALE |
PD184352 (CI-1040) |
MEK1/2 抑制剂 |
PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
|
A10957 SALE |
U0126-EtOH |
MEK 抑制剂 |
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
|
A10089 SALE |
AS703026 (Pimasertib) |
MEK1/2 抑制剂 |
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.
|
A11029 SALE |
GSK1120212 (JTP-74057, Trametinib) |
MEK 抑制剂 |
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
|
A10151 SALE |
BIX 02189 |
MEK 抑制剂 |
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
|
A11040 SALE |
TAK-733 |
MEK 抑制剂 |
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
|
A10115 |
AZD8330 |
MEK 抑制剂 |
AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
|
A10704 |
PD318088 |
MEK 抑制剂 |
PD318088 is an inhibitor of MEK1 AND MEK2.
|
A10150 |
BIX02188 |
MEK5 抑制剂 |
BIX02188 is a potent and selective inhibitor of MEK5.
|
A11441 SALE |
GDC-0973 (Cobimetinib) |
MEK1 抑制剂 |
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
|
A11493 SALE |
MEK162 (ARRY-438162, Binimetinib) |
MEK1/2 抑制剂 |
MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
|
A11247 |
RO4927350 |
MEK1/2 抑制剂 |
RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
|
A12866 |
Refametinib (RDEA-119, BAY 86-9766) |
MEK1/2 抑制剂 |
Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity.
|
A13119 |
Balamapimod (MKI-833) |
Ras/Raf/MEK 抑制剂 |
Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor.
|
A14019 |
RO5126766 (CH5126766) |
Raf/MEK dual 抑制剂 |
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
|
A13750 |
Hypothemycin |
- |
Hypothemycin is a resorcylic acid lactone polyketide. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone.
|
A13272 |
RO4987655 |
MEK1 抑制剂 |
RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity.
|
A11225 |
Pluripotin (SC-1) |
ERK1/RasGAP 抑制剂 |
The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.
|
A11794 SALE |
Ulixertinib (BVD-523, VRT752271) |
ERK1/ERK2 抑制剂 |
VRT752271 is a pyrrole inhibitors of ERK protein kinase.
|
A12824 SALE |
SCH772984 |
ERK 抑制剂 |
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
|
A12505 SALE |
TCS ERK 11e (VX-11e) |
ERK2 抑制剂 |
TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
|
A13420 SALE |
GDC0994 |
ERK1/2 抑制剂 |
GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
|
A14090 |
XMD 17-109 |
ERK5 抑制剂 |
XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells.
|
A14119 SALE |
FR 180204 |
ERK 抑制剂 |
FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.
|
A11609 SALE |
XMD8-92 |
BMK1/ERK5 抑制剂 |
XMD8-92 is a potent and selective BMK1/ERK5 inhibitor .
|
A13977 |
TMCB |
CK2/ERK8 抑制剂 |
MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).
|
A15802 SALE |
DEL-22379 |
ERK 抑制剂 |
DEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes.
|
A16231 |
APS-2-79 |
KSR/Ras 抑制剂 |
APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
|
A16232 |
ERK5-IN-1 |
ERK5 抑制剂 |
ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM.
|
A16233 |
Tomatidine |
ERK/Akt/NF-kB 抑制剂 |
Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties.
|
A13678 |
SB-242235 |
p38 MAPK 抑制剂 |
SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases.
|
A13552 |
RWJ-67657 |
p38 MAPK 抑制剂 |
RWJ-67657 is a potent p38 MAPK inhibitor.
|
A13563 |
BMS-582949 |
p38 MAPK 抑制剂 |
BMS-582949 Is a Dual Action p38 Kinase Inhibitor Well Suited To Avoid Resistance Mechanisms That Increase p38 Activation in Cells.
|
A10895 |
Pexmetinib (ARRY-614) |
p38 MAPK 抑制剂 |
Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
|
A10970 |
AMG 548 |
p38 MAPK 抑制剂 |
AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
|
A11101 |
SKF 86002 Dihydrochloride |
p38 MAPK 抑制剂 |
SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM).
|
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- Abl (1)
- Aurora A (1)
- Aurora B (2)
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- C-Raf (Raf-1) (17)
- CDK2 (1)
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- ERK5 (1)
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- p38α (1)
- PDGFRα (1)
- PDGFRβ (5)
- Raf (3)
- RET (3)
- RKIP (1)
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- SRMS (1)
- VEGFR1 (FLT1) (2)
- VEGFR2 (FLK1) (4)
- VEGFR3 (FLT4) (2)
- Mechanism of action