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DNA Damage | DNA 损伤

产品 1 到 50 共 299个

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Catalog No. Product Name Application Product Information
A14128 SALE

TMP 269

HDAC 抑制剂
TMP 269 is a potent, selective class IIa HDAC inhibitor with IC50 of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

RG2833 (RGFP109)

HDAC 抑制剂
RG2833 ( is a brain-penetrant HDAC inhibitor with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3.

Resminostat hydrochloride

HDAC 抑制剂
Resminostat hydrochloride is a potent inhibitor of HDAC1/3/6(IC50=43-72 nM); less potent to HDAC8 with IC50 of 877 nM.

KD 5170

HDAC 抑制剂
KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.

NCH 51

HDAC 抑制剂
NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM.

NSC 3852

HDAC 抑制剂
NSC 3852 is an HDAC (histone deacetylase) inhibitor.

TC-H 106

HDAC 抑制剂
TC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases).


HDAC6 抑制剂
TCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen.


HDAC 抑制剂
R306465 is a novel hydroxamate-based histone deacetylase (HDAC) inhibitor with broad-spectrum antitumour activity against solid and haematological malignancies in preclinical models.
A15934 SALE


HDAC6 抑制剂
ACY-738 is a potent and selective HDAC6 inhibitor with improved brain bioavailability. ACY-738 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.
A15935 SALE


HDAC 抑制剂?€?
BML-210 is HDAC inhibitor. BML-210 induces growth inhibition and apoptosis and regulates HDAC and DAPC complex expression levels in cervical cancer cells.


HDAC 抑制剂
M344 is a potent inhibitor of HDAC with IC50 of 100 nM and able to induce cell differentiation.


HDAC 抑制剂
BG45 is an HDAC class I inhibitor with selectivity for HDAC3 (IC50 = 289 nM). It inhibits HDAC1, HDAC2, and HDAC6 with greatly reduced potency (IC50s = 2, 2.2, and >20 μM, respectively).


HDAC 抑制剂
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors.
A10611 SALE

MS-275 (Entinostat)

HDAC 抑制剂
MS-275 (Entinostat) is a potent HDAC inhibitor with IC50 of 0.3 and 8uM for HDAC1 and HDAC3, respectively.
A10947 SALE

Trichostatin-A (TSA)

HDAC 抑制剂
Trichostatin A (TSA) inhibits the HDACs 1, 3, 4, 6 and 10 with IC50 values around 20 nM.
A10122 SALE

Belinostat (PXD101)

HDAC 抑制剂
Belinostat (PXD101) is a HDAC inhibitor that inhibits HDAC activity in HeLa cell extracts with an IC50 of 27 nM.
A10518 SALE

LBH589 (Panobinostat)

HDAC 抑制剂
LBH589 is a hydroxamic acid and acts as a non-selective HDAC inhibitor with IC5o of HDAC1 to be 0.23 nM.
A10560 SALE


HDAC 抑制剂
MC1568 is a member of HDAC inhibitors that inhibits the histone deacetylase class II by modifying the genetic expression of various important genes of cell cycle mostly at G1 phase, resulting in the death of breast cancer cells by apoptosis.
A10246 SALE


HDAC 抑制剂
CUDC-101 is a novel compound which inhibits multiple targets, which is designed to inhibit HDAC, EGFR and Her2.

MGCD0103 (Mocetinostat)

HDAC 抑制剂
MGCD0103 (Mocetinostat) is a benzamide histone deacetylase inhibitor by inhibiting mainly histone deacetylase 1 (HDAC1), but also HDAC2, HDAC3, and HDAC11.
A10979 SALE

Vorinostat (SAHA)

HDAC 抑制剂
Vorinostat is an inhibitor of HDACs, inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors.

ITF2357 (Givinostat)

HDAC 抑制剂
ITF2357 (Givinostat) is a HDACs inhibitor with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities.
A10337 SALE


HDAC 抑制剂
Droxinostat is a selective inhibitor of HDAC3, HDAC6, and HDAC8 that shows comparable inhibition of HDAC6 and HDAC8 with IC50 = 2.47 and 1.46 μmol/L, respectively.

AR-42 (HDAC-42)

HDAC 抑制剂
AR-42 is a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.
A10700 SALE

PCI-24781 (Abexinostat)

HDAC 抑制剂
PCI-24781 is a broad-spectrum phenyl hydroxamic acid HDAC inhibitor.
A11042 SALE

Tubastatin A HCl

HDAC6 抑制剂
Tubastatin A is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in a cell-free assay. It is selective against all the other isozymes (1000-fold) except HDAC8 (57-fold).

SB939 ( Pracinostat )

HDAC 抑制剂
SB939 is an oral inhibitor of HDAC, selective for class I, II and IV HDACs and displays an IC50 value of 77 nM in an in vitro HDAC1 activity assay.
A10492 SALE


HDAC 抑制剂
JNJ-26481585 is a pan-HDAC inhibitor with marked potency toward HDAC1 (IC(50), 0.16 nmol/L).
A10764 SALE

Pyroxamide (NSC 696085)

HDAC 抑制剂
Pyroxamide (NSC 696085) is a potent inhibitor of affinity-purified HDAC1 and causes the accumulation of acetylated core histones in MEL cells cultured with the agent.
A11152 SALE


HDAC 抑制剂
PCI-34051 is a specific and potent histone deacetylase 8 (HDAC8) inhibitor, with >200-fold selectivity over the other HDAC isoforms.
A11153 SALE


HDAC 抑制剂
CUDC-907 is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
A10698 SALE

Parthenolide ((-)-Parthenolide)

Parthenolide ((-)-Parthenolide) is a sesquiterpene lactone which occurs naturally in the plant feverfew (Tanacetum parthenium).


HDAC6 抑制剂
Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM.
A10516 SALE

LAQ824 (NVP-LAQ824, Dacinostat)

HDAC 抑制剂
LAQ824 (NVP-LAQ824) is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
A11940 SALE

ACY-1215 (Rocilinostat)

HDAC6 抑制剂
ACY-1215 selectively targets and binds to HDAC6, thereby disrupting the Hsp90 protein chaperone system through hyperacetylation of Hsp90 and preventing the subsequent aggresomal protein degradation.
A11964 SALE

CI994 (Tacedinaline)

HDAC 抑制剂
CI-994 is a histone deacetylase (HDAC) inhibitor and induces histone hyperacetylation in living cells.
A11920 SALE

Romidepsin (FK228 ,Depsipeptide)

HDAC 抑制剂
Romidepsin strongly inhibits HDAC1 and HDAC2 with IC5N/A of 1.6 nM and 3.9 nM, respectively, but is relatively weak in inhibiting HDAC4 and HDAC6 with IC5N/A 25 nM and 79N/A nM, respectively.


HDAC 抑制剂
Apicidin is a a potent histone deacetylases (HDAC) inhibitor with potential anticancer activity.
A13218 SALE


HDAC3 抑制剂
RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC.


HDAC6 抑制剂
BRD9757 is a highly potent and selective HDAC6 inhibitor with an IC50 of 30 nM toward HDAC6.
A12556 SALE


HDAC 抑制剂
Resminostat, also known as RAS2410, is a potent inhibitor of histone deacetylase (HDAC) classes I and II. It binds to and inhibits HDACs leading to an accumulation of highly acetylated histones.


HDAC 抑制剂
Scriptaid is an HDAC inhibitor (histone deacetylase).

Nexturastat A

HDAC6 抑制剂
Nexturastat A is an aryl urea derivative that acts as a potent and highly selective inhibitor of histone deacetylase 6 (HDAC6) (IC50= 5.02 +/- 0.60 nM).
A14197 SALE


HDAC6 抑制剂
HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).


NAD(+)-dependent histone deacetylase Sir2p 抑制剂
Splitomicin is a selective NAD(+)-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 uM, showing a higher activity in a cell-based assay.
A12616 SALE


HDAC4 抑制剂
Tasquinimod is an orally active antiangiogenic agent by allosterically inhibiting HDAC4 signalling.

Santacruzamate A

HDAC 抑制剂
Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor with IC50 of 119 pM for HDAC2, >3600-fold selectivity over other HDACs.
A14341 SALE


HDAC4/5 抑制剂
LMK-235 is a selective histone deacetylase (HDAC) 4 and HDAC5 inhibitor.


HDAC 抑制剂
ST7612AA1 is a new and potent HDAC inhibitor with potential anticancer activity.

产品 1 到 50 共 299个

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