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Neuronal | 神经信号通路

Neuronal | 神经信号通路

Catalog No.	Product Name	Application	Product Information
A10802 SALE	RO4929097	Gamma-secretase 抑制剂	RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
A10157	BMS-708163 (Avagacestat)	Gamma-secretase 抑制剂	BMS-708163 is an oral gamma secretase inhibitor designed for selective inhibition of amyloid beta synthesis.
A11194 SALE	MK-0752	Gamma-secretase 抑制剂	MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
A10312 SALE	Dimebon 2HCl	Neuroprotectant	Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities.
A11776 SALE	LY2811376	BACE1 抑制剂	LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
A12647	Ro 90-7501	amyloid ??42 抑制剂	Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).
A15424	Amyloid b-Protein (1-15)	-	Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
A15423	beta-Amyloid (1-11)	-	Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
A15421	Amyloid b-Peptide (1-43) (human)	-	Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42.
A15420	Amyloid b-peptide (1-42) (rat)	-	Amyloid b-peptide (1-42) (rat)
A15419	Amyloid b-peptide (1-40) (rat)	-	Amyloid b-peptide (1-40) (rat)
A15418	Amyloid b-Peptide (1-40) (human)	-	Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP).
A15416 SALE	Amyloid b-peptide (25-35) (human)	-	Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.
A15417	Amyloid b-Peptide (12-28) (human)	-	Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins.
A15415	Amyloid b-Peptide (10-20) (human)	-	Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
A15414	Amyloid b-peptide (42-1) (human)	-	Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.
A14075	Amyloid b-Peptide (1-42) (human)	-	Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
A13094	alpha-Amyloid Precursor Protein Modulator	-
A10288 SALE	DAPT (GSI-IX)	Gamma secretase 抑制剂	DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
A11174 SALE	YO-01027	??-secretase 抑制剂	YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
A11176 SALE	LY-411575	Gamma secretase 抑制剂	LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor.
A10836 SALE	Semagacestat (LY450139)	Gamma-secretase 抑制剂	Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM. Product Citations (2) R Yesuvadian ,etc. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: A high-resolution NMR study. Biochemical and biophysical research communications, 2014, 447(4), 590-595. Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.
A11337	BMS 433796	??-Secretase 抑制剂	BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
A11393	E 2012	gamma-secretase modulator	E 2012 is γ-secretase inhibitor. Product Citations (1) R Yesuvadian ,etc. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: A high-resolution NMR study. Biochemical and biophysical research communications, 2014, 447(4), 590-595.
A12444	BMS 299897	??-secretase 抑制剂	BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
A12433	Flurizan	gamma-secretase modulator	Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
A13815 SALE	FLI-06	Gamma-secretase 抑制剂	FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
A13544 SALE	LY3039478	Notch 抑制剂	LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.
A15090	gamma-secretase modulator 3	gamma-secretase modulator	gamma-secretase modulator 3 is a gamma-secretase modulator.
A15296	Compound W	Gamma-secretase modulator	Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
A15301	JLK 6	??-secretase 抑制剂	JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.
A15304	MRK 560	??-secretase 抑制剂	MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
A11259	PF-03084014	??-secretase 抑制剂	PF-03084014 is a reversible and selective inhibitor of ??-secretase with IC50 value of 6.2 nM .
A13662	Flurbiprofen Axetil	gamma-secretase 抑制剂	Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
A15899	L-685458	??-secretase 抑制剂	L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
A13319	PF-03084014	??-secretase 抑制剂	PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2.
A11258	Begacestat (GSI-953)	??-secretase 抑制剂	Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
A11425	gamma-secretase modulator 1	Gamma-secretase modulator	gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.
A11427	gamma-secretase modulator 2	Gamma-secretase modulator	gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.
A13217	TC-E 5006	Gamma-secretase modulator	TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.
A16152	IMR-1	Notch 抑制剂	IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.
A16214	CHF5074	??-Secretase modulator	CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively.
A16215	Z-Ile-Leu-aldehyde	??-Secretase 抑制剂	Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.
A16223	IMR-1A	Notch 抑制剂	IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.
A14088	LY-900009	Notch 抑制剂	LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM.
A10543	LY2886721	BACE1 抑制剂	LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments. Product Citations (1) N Ito ,etc. miR‐15b mediates oxaliplatin‐induced chronic neuropathic pain through BACE1 downregulation. British Journal of Pharmacology, 2016, 174(5):386-395..
A12825	AZD3839	BACE1 抑制剂	AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM.
A13249	AZD5423	nonsteroidal glucocorticoid receptor 激动剂	AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist.
A14407	AMG-8718	BACE1 抑制剂	AMG-8718 is a potent and orally efficacious BACE1 inhibitor.
A14591	Timosaponin b-II	BACE1 抑制剂	Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage.

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Neuronal | 神经信号通路

A10802 SALE

A10157

A11194 SALE

A10312 SALE

A11776 SALE

A12647

A15424

A15423

A15421

A15420

A15419

A15418

A15416 SALE

A15417

A15415

A15414

A14075

A13094

A10288 SALE

A11174 SALE

A11176 SALE

A10836 SALE

A11337

A11393

A12444

A12433

A13815 SALE

A13544 SALE

A15090

A15296

A15301

A15304

A11259

A13662

A15899

A13319

A11258

A11425

A11427

A13217

A16152

A16214

A16215

A16223

A14088

A10543

A12825

A13249

A14407

A14591