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Neuronal | 神经信号通路
Catalog No. | Product Name | Application | Product Information |
---|---|---|---|
A10802 SALE |
RO4929097 |
Gamma-secretase 抑制剂 |
RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM.
|
A10157 |
BMS-708163 (Avagacestat) |
Gamma-secretase 抑制剂 |
BMS-708163 is an oral gamma secretase inhibitor designed for selective
inhibition of amyloid beta synthesis.
|
A11194 SALE |
MK-0752 |
Gamma-secretase 抑制剂 |
MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
|
A10312 SALE |
Dimebon 2HCl |
Neuroprotectant |
Dimebon dihydrochloride is a non-selective antihistamine that displays cognitive enhancing abilities.
|
A11776 SALE |
LY2811376 |
BACE1 抑制剂 |
LY2811376 is the first orally available non-peptidic BACE1 inhibitor that produces profound Aβ-lowering effects in animals.
|
A12647 |
Ro 90-7501 |
amyloid ??42 抑制剂 |
Ro 90-7501 is an inhibitor of amyloid β42 (Aβ42) fibril assembly; reduces Aβ42-induced toxicity (EC50 = 2 μM).
|
A15424 |
Amyloid b-Protein (1-15)
|
- |
Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
|
A15423 |
beta-Amyloid (1-11)
|
- |
Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
|
A15421 |
Amyloid b-Peptide (1-43) (human)
|
- |
Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42.
|
A15420 |
Amyloid b-peptide (1-42) (rat)
|
- |
Amyloid b-peptide (1-42) (rat)
|
A15419 |
Amyloid b-peptide (1-40) (rat)
|
- |
Amyloid b-peptide (1-40) (rat)
|
A15418 |
Amyloid b-Peptide (1-40) (human)
|
- |
Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP).
|
A15416 SALE |
Amyloid b-peptide (25-35) (human) |
- |
Amyloid b-peptide (25-35) (human), fragment of human amyloid beta-peptide, functionally required for the neurotrophic and neurotoxic effects associated with Alzheimer's disease.
|
A15417 |
Amyloid b-Peptide (12-28) (human)
|
- |
Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins.
|
A15415 |
Amyloid b-Peptide (10-20) (human)
|
- |
Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
|
A15414 |
Amyloid b-peptide (42-1) (human)
|
- |
Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.
|
A14075 |
Amyloid b-Peptide (1-42) (human) |
- |
Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease.
|
A13094 |
alpha-Amyloid Precursor Protein Modulator |
- |
|
A10288 SALE |
DAPT (GSI-IX) |
Gamma secretase 抑制剂 |
DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
|
A11174 SALE |
YO-01027 |
??-secretase 抑制剂 |
YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
|
A11176 SALE |
LY-411575 |
Gamma secretase 抑制剂 |
LY-411575 is a selective, cell permeable, small molecule gamma secretase inhibitor. |
A10836 SALE |
Semagacestat (LY450139) |
Gamma-secretase 抑制剂 |
Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
|
A11337 |
BMS 433796 |
??-Secretase 抑制剂 |
BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheimer's disease.
|
A11393 |
E 2012 |
gamma-secretase modulator |
E 2012 is γ-secretase inhibitor.
|
A12444 |
BMS 299897 |
??-secretase 抑制剂 |
BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.
|
A12433 |
Flurizan |
gamma-secretase modulator |
Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
|
A13815 SALE |
FLI-06 |
Gamma-secretase 抑制剂 |
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
|
A13544 SALE |
LY3039478 |
Notch 抑制剂 |
LY3039478 is a orally bioavailable, novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.
|
A15090 |
gamma-secretase modulator 3 |
gamma-secretase modulator |
gamma-secretase modulator 3 is a gamma-secretase modulator.
|
A15296 |
Compound W
|
Gamma-secretase modulator |
Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
|
A15301 |
JLK 6
|
??-secretase 抑制剂 |
JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.
|
A15304 |
MRK 560
|
??-secretase 抑制剂 |
MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
|
A11259 |
PF-03084014 |
??-secretase 抑制剂 |
PF-03084014 is a reversible and selective inhibitor of ??-secretase with IC50 value of 6.2 nM .
|
A13662 |
Flurbiprofen Axetil |
gamma-secretase 抑制剂 |
Flurbiprofen Axetil is potentnon-steroidal anti-inflammatory drug(NSAID).
|
A15899 |
L-685458 |
??-secretase 抑制剂 |
L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
|
A13319 |
PF-03084014 |
??-secretase 抑制剂 |
PF-03084014 (PF-3084014) is a selective gamma-secretase inhibitor with IC50 of 6.2 nM in a cell-free assay. Phase 2.
|
A11258 |
Begacestat (GSI-953) |
??-secretase 抑制剂 |
Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.
|
A11425 |
gamma-secretase modulator 1 |
Gamma-secretase modulator |
gamma-secretase modulator 1 is a gamma-secretase modulator, gamma-secretase modulator 1 is useful for Alzheimer's disease.
|
A11427 |
gamma-secretase modulator 2 |
Gamma-secretase modulator |
gamma-secretase modulator 2 is a potent and selective gamma-secretase modulator for treatment of Alzheimer's disease.
|
A13217 |
TC-E 5006 |
Gamma-secretase modulator |
TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo.
|
A16152 |
IMR-1 |
Notch 抑制剂 |
IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.
|
A16214 |
CHF5074 |
??-Secretase modulator |
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 uM, respectively.
|
A16215 |
Z-Ile-Leu-aldehyde |
??-Secretase 抑制剂 |
Z-Ile-Leu-aldehyde is a potent gamma-Secretase inhibitor; Notch signaling inhibitor.
|
A16223 |
IMR-1A |
Notch 抑制剂 |
IMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.
|
A14088 |
LY-900009 |
Notch 抑制剂 |
LY-900009 is a potent inhibitor of Notch with IC50 value of 0.27 nM.
|
A10543 |
LY2886721 |
BACE1 抑制剂 |
LY2886721 is a novel potent agent that is used to treat Alzheimer's Disease in preclinical experiments.
|
A12825 |
AZD3839 |
BACE1 抑制剂 |
AZD3839 is a potent and selective inhibitor of human BACE1 with Ki of 26.1 nM.
|
A13249 |
AZD5423 |
nonsteroidal glucocorticoid receptor 激动剂 |
AZD5423 is a novel nonsteroidal glucocorticoid receptor agonist.
|
A14407 |
AMG-8718 |
BACE1 抑制剂 |
AMG-8718 is a potent and orally efficacious BACE1 inhibitor.
|
A14591 |
Timosaponin b-II |
BACE1 抑制剂 |
Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage.
|