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(S,R,S)-AHPC-C3-NH2
Catalog No. A18818 E3 ligase ligand-linker conjugate(S,R,S)-AHPC-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used in PROTAC technology. 了解更多 -
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH
Catalog No. A18842 E3 ligase ligand-linker conjugatePomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多 -
Pomalidomide-C2-NH2
Catalog No. A18855 E3 ligase ligand-linker conjugatePomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology. 了解更多 -
CCK2R Ligand-Linker Conjugates 1
Catalog No. A18411 ligand-linker conjugateCCK2R Ligand-Linker Conjugates 1 is a ligand-linker conjugate, which conjugates to the cytotoxic antimicrotubule agents Desacetyl Vinblastine Hydrazide (DAVBH) and Tubulysin B Hydrazide (TubBH) via a hydrophilic peptide linker. 了解更多 -
Pomalidomide-PEG4-Ph-NH2
Catalog No. A12066 E3 ligase ligand-linker conjugatePomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. 了解更多 -
Thalidomide-O-amido-PEG2-C2-NH2 (TFA)
Catalog No. A21634 E3 ligase ligand-linker conjugateThalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology. 了解更多 -
Thalidomide-O-amido-C6-NH2 (TFA)
Catalog No. A21639 E3 ligase ligand-linker conjugateThalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多 -
(S,R,S)-AHPC-PEG3-NH2
Catalog No. A21660 E3 ligase ligand-linker conjugate(S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. 了解更多 -
(S,R,S)-AHPC-PEG2-NH2
Catalog No. A21665 E3 ligase ligand-linker conjugate(S,R,S)-AHPC-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. 了解更多 -
(S,R,S)-AHPC-PEG4-NH2
Catalog No. A21671 E3 ligase ligand-linker conjugate(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. 了解更多 -
Pomalidomide-C2-NH2 hydrochloride
Catalog No. A21768 E3 ligase ligand-linker conjugatePomalidomide-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多 -
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride
Catalog No. A21753 E3 ligase ligand-linker conjugatecIAP1 Ligand-Linker Conjugates 11 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride can be used to design SNIPERs. 了解更多 -
Lenalidomide-C5-NH2
Catalog No. A18414 Lenalidomide-based Cereblon ligandLenalidomide-C5-NH2 is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C5-NH2 can be connected to the ligand for protein by a linker to form PROTACs. 了解更多 -
cIAP1 Ligand-Linker Conjugates 15 hydrochloride
Catalog No. A21758 E3 ligase ligand-linker conjugatecIAP1 Ligand-Linker Conjugates 15 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 hydrochloride can be used to design SNIPERs. 了解更多 -
Thalidomide-O-amido-C3-NH2 (TFA)
Catalog No. A21801 E3 ligase ligand-linker conjugateThalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology. 了解更多 -
E3 ligase Ligand 9
Catalog No. A19051 E3 ubiquitin ligase ligandE3 ligase Ligand 9 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 9 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. 了解更多 -
E3 ligase Ligand 10
Catalog No. A19045 E3 ubiquitin ligase ligandE3 ligase Ligand 10 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 10 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. 了解更多 -
E3 ligase Ligand 14
Catalog No. A19028 E3 ubiquitin ligase ligandE3 ligase Ligand 14 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 14 can be connected to the ligand for protein by a linker to form PROTACs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins. 了解更多 -
VH032-cyclopropane-F
Catalog No. A18417 VH032-based VHL ligandVH032-cyclopropane-F is the VH032-based VHL ligand. VH032-cyclopropane-F can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). 了解更多 -
Thalidomide fluoride
Catalog No. A12144 Thalidomide-based Cereblon ligandThalidomide fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966). 了解更多 -
PROTAC BET degrader-2
Catalog No. A18785 PROTAC BET degraderPROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. 了解更多 -
dBET1
Catalog No. A16858 -
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MZ1
Catalog No. A17014 -
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PROTAC CRBN Degrader-1
Catalog No. A18863 CRBN degraderPROTAC CRBN Degrader-1 comprises a cereblon (CRBN) ligand binding group, a linker and an von Hippel-Landau (VHL) binding group. PROTAC CRBN Degrader-1 is an cereblon (CRBN) degrader. 了解更多 -
PROTAC FLT-3 degrader 1
Catalog No. A18682 FLT-3 ITD degraderPROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction. 了解更多 -
PROTAC ER Degrader-3
Catalog No. A18519 PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多 -
PROTAC Sirt2 Degrader-1
Catalog No. A20005 Sirt2 degraderPROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. 了解更多 -
PROTAC Bcl2 degrader-1
Catalog No. A18355 degraderPROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1. 了解更多 -
PROTAC Mcl1 degrader-1
Catalog No. A18373 Mcl-1 inhibitorPROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC), is a potently and selectively Mcl-1 inhibitor with an IC50 of 0.78 μM. 了解更多 -
FKBP12 PROTAC dTAG-7
Catalog No. A19081 heterobifunctional degraderFKBP12 PROTAC dTAG-7 (dTAG-7) is a heterobifunctional degrader. 了解更多 -
PROTAC ERRα Degrader-2
Catalog No. A18904 ERRa degraderPROTAC ERRalpha Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRalpha Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多 -
THAL-SNS-032
Catalog No. A19088 CDK9 degrader PROTACTHAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN). 了解更多 -
Gefitinib-based PROTAC 3
Catalog No. A19093 Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively. 了解更多 -
PROTAC ERRα Degrader-1
Catalog No. A18910 ERRα DegraderPROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多
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- E3 Ligase Ligand-Linker Conjugate (15)
- E3 Ligase Ligands (7)
- PROTAC Degrader (29)
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- Inhibitor (抑制剂) (2)
- Agonist (激动剂) (1)
- Modulator (调节剂) (1)
- Degrader (降解剂) (23)
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