您的购物车内没有物品。
微信关注Stem Cells / Wnt 信号通路
| Catalog No. | Product Name | Application | Product Information |
|---|---|---|---|
A10258 SALE |
GDC-0449 (Vismodegib) |
Hedgehog 拮抗剂 |
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
|
A10249 |
Cyclopamine |
Hedgehog signaling 抑制剂 |
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
|
A11048 SALE |
LY2940680 (Taladegib) |
SMO 拮抗剂 |
LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.
|
A11351 |
TAK-441 |
Hedgehog 抑制剂 |
TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.
|
A13095 SALE |
SANT-1 |
Sonic hedgehog 抑制剂 |
SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
|
A13252 SALE |
GANT61 |
GLI 拮抗剂 |
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
|
A11442 |
GANT 58 |
GLI 拮抗剂 |
|
A12920 |
Hh-Ag1.5 |
Hedgehog 抑制剂 |
Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
|
A12418 |
HhAntag |
- |
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
|
A16111 |
MK-4101 |
Hedgehog 抑制剂 |
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.
|
A16229 |
RU-SKI 43 |
Hhat 抑制剂 |
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
|
A16349 |
HPI-4 |
hedgehog 抑制剂 |
HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.
|
A13192 |
IWP-3
|
Wnt 抑制剂 |
IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
|
A15851 SALE |
BML-284 (Wnt agonist 1) |
Wnt 激动剂 1 |
Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM.
|
A15840 |
ETC-159 |
Wnt 抑制剂 |
ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits beta-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.
|
A16064 SALE |
IQ-1 |
Wnt/beta-catenin 抑制剂 |
IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling.
|
A16094 |
WAY-262611 |
Wnt pathway activator |
WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay.
|
A16216 |
CCT251545 |
Wnt 抑制剂 |
CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.
|
A16217 |
Hexachlorophene |
Wnt/beta-catenin 抑制剂 |
Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling.
|
A16219 |
JW74 |
Wnt 抑制剂 |
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.
|
A11039 SALE |
ICG-001 |
Wnt/beta-catenin 抑制剂 |
ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) .
|
A10994 SALE |
XAV 939 |
PARP 抑制剂 |
XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively).
|
A12362 SALE |
KY02111 |
Wnt 抑制剂 |
KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation.
|
A12816 SALE |
LGK-974 |
PORCN 抑制剂 |
LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
|
A12737 SALE |
IWR-1-endo |
Wnt 抑制剂 |
IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
|
A12707 SALE |
IWP-2 |
Wnt 抑制剂 |
IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.
|
A12951 SALE |
Wnt-C59 |
PORCN/Wnt 抑制剂 |
Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
|
A13978 SALE |
IWP-L6 |
PORCN 抑制剂 |
IWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM).
|
A15229 SALE |
Salinomycin sodium salt |
- |
Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
|
A15856 |
PRI-724 |
CBP/beta-catenin 拮抗剂 |
PRI-724, an isomer or enantiomer of ICG-001 (A11039), is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. |
A16198 |
Cardiogenol C HCl |
- |
Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells.
|
A16353 |
KYA1797K |
Wnt/beta-catenin 抑制剂 |
KYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay).
|
A13795 |
FH535 |
??-Catenin/Tcf 抑制剂 |
|
A13986 |
WAY-316606 |
sFRP-1 抑制剂 |
WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
|
A15773 |
Cardiogenol C hydrochloride
|
- |
Cardiogenol C hydrochloride is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.
|
A16218 SALE |
iCRT 14 |
CRT 抑制剂 |
iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity).
|
A11060 SALE |
CX-4945 (Silmitasertib) |
CK2 抑制剂 |
CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
|
A13574 |
LH 846 |
CK1 抑制剂 |
LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α)
|
A13949 SALE |
D4476 |
CK1 抑制剂 |
D4476 is a cell-permeant inhibitor of casein kinase 1.
|
A14101 |
TTP-22 |
CK2 抑制剂 |
TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.
|
A15069 SALE |
DMAT |
CK2 抑制剂 |
DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM.
|
A15257 |
TBB |
CK2 抑制剂 |
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 uM for rat liver and human recombinant CK2 respectively).
|
A15764 SALE |
IC 261 |
CK1?? and CK1?? 抑制剂 |
IC 261 is CK1δ and CK1ε inhibitor.
|
A16234 |
CX-4945 sodium salt |
CK2 抑制剂 |
CX-4945 sodium salt is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively.
|
A16235 |
SR-3029 |
CK1??/CK1?? 抑制剂 |
SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor with the IC50 of 97 nM.
|
A16236 |
TA-01 |
CK 抑制剂 |
TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively).
|
A11781 |
PF 670462 |
Casein kinase 抑制剂 |
Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
|
A10344 SALE |
Ellagic acid |
- |
Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption.
|
A13584 |
A-3 Hydrochloride |
PKA, PKG, Casein Kinase I and II 抑制剂 |
A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
|
A13977 |
TMCB |
CK2/ERK8 抑制剂 |
MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).
|
FILTER BY:
购物选项
- 研究领域
-
- Hedgehog (12)
- Wnt (20)
- β-catenin (11)
- Casein Kinase (14)
- Smoothened (7)
- GSK-3 (19)
- Hippo (2)
- γ-Secretase (31)
- Mechanism of action
-
- Activator (2)
- Agonist (2)
- Antagonist (5)
- Inhibitor (87)
- Modulator (8)