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Stem Cells / Wnt 信号通路

Stem Cells / Wnt 信号通路

Catalog No.	Product Name	Application	Product Information
A10258 SALE	GDC-0449 (Vismodegib)	Hedgehog 拮抗剂	GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM. Product Citations (2) Yi Yang,et al. Tumidulin, a Lichen Secondary Metabolite, Decreases the Stemness Potential of Colorectal Cancer Cells, Molecules, 2018, Nov; 23(11): 2968 30441806 Olesen UH,et al. Topical delivery of vismodegib using ablative fractional laser and micro-emulsion formulation in vitro, Lasers Surg Med, 2018, Aug 28 30152536
A10249	Cyclopamine	Hedgehog signaling 抑制剂	Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
A11048 SALE	LY2940680 (Taladegib)	SMO 拮抗剂	LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.
A11351	TAK-441	Hedgehog 抑制剂	TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.
A13095 SALE	SANT-1	Sonic hedgehog 抑制剂	SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
A13252 SALE	GANT61	GLI 拮抗剂	GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation. Product Citations (1) Hui Liang,et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 28098170
A11442	GANT 58	GLI 拮抗剂
A12920	Hh-Ag1.5	Hedgehog 抑制剂	Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
A12418	HhAntag	-	HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
A16111	MK-4101	Hedgehog 抑制剂	MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.
A16229	RU-SKI 43	Hhat 抑制剂	RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
A16349	HPI-4	hedgehog 抑制剂	HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.
A13192	IWP-3	Wnt 抑制剂	IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
A15851 SALE	BML-284 (Wnt agonist 1)	Wnt 激动剂 1	Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM.
A15840	ETC-159	Wnt 抑制剂	ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits beta-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.
A16064 SALE	IQ-1	Wnt/beta-catenin 抑制剂	IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling.
A16094	WAY-262611	Wnt pathway activator	WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay.
A16216	CCT251545	Wnt 抑制剂	CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.
A16217	Hexachlorophene	Wnt/beta-catenin 抑制剂	Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling.
A16219	JW74	Wnt 抑制剂	JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM. Product Citations (1) Yang JM,et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/汕-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 30205152
A11039 SALE	ICG-001	Wnt/beta-catenin 抑制剂	ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) . Product Citations (2) Yamaoka R,et al. CD90 expression in human intrahepatic cholangiocarcinoma is associated with lymph node metastasis and poor prognosis, J Surg Oncol, 2018, Sep;118(4):664-674 30196535 Aida Y,et al. Wnt3a promotes differentiation of human bone marrow-derived mesenchymal stem cells into cementoblast-like cells, In Vitro Cell Dev Biol Anim, 2018, Jun;54(6):468-476 29785536
A10994 SALE	XAV 939	PARP 抑制剂	XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively). Product Citations (2) Shizu Aikawa,et al. Autotaxin-lysophosphatidic acid-LPA 3 signaling at the embryo坼epithelial boundary controls decidualization pathways, EMBO J, 2017, Jul 14; 36(14): 2146-2160 28588064 Mika?l M. Martino,et al. Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration, Nat Commun, 2016, 7: 11051 27001940
A12362 SALE	KY02111	Wnt 抑制剂	KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation.
A12816 SALE	LGK-974	PORCN 抑制剂	LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay. Product Citations (2) Yang JM,et al. LGK974, a PORCUPINE inhibitor, mitigates cytotoxicity in an in vitro model of Parkinson's disease by interfering with the WNT/汕-CATENIN pathway, Toxicology, 2018, Dec 1;410:65-72 30205152 E Lemieux,et al. Oncogenic KRAS signalling promotes the Wnt/汕-catenin pathway through LRP6 in colorectal cancer, Oncogene, 2015, Sep 17; 34(38): 4914-4927 25500543
A12737 SALE	IWR-1-endo	Wnt 抑制剂	IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
A12707 SALE	IWP-2	Wnt 抑制剂	IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.
A12951 SALE	Wnt-C59	PORCN/Wnt 抑制剂	Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
A13978 SALE	IWP-L6	PORCN 抑制剂	IWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM).
A15229 SALE	Salinomycin sodium salt	-	Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
A15856	PRI-724	CBP/beta-catenin 拮抗剂	PRI-724, an isomer or enantiomer of ICG-001 (A11039), is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.
A16198	Cardiogenol C HCl	-	Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells.
A16353	KYA1797K	Wnt/beta-catenin 抑制剂	KYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay).
A13795	FH535	??-Catenin/Tcf 抑制剂	Product Citations (1) Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546–1558.
A13986	WAY-316606	sFRP-1 抑制剂	WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
A15773	Cardiogenol C hydrochloride	-	Cardiogenol C hydrochloride is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.
A16218 SALE	iCRT 14	CRT 抑制剂	iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity).
A11060 SALE	CX-4945 (Silmitasertib)	CK2 抑制剂	CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells. Product Citations (7) Fukumoto Y,et al. Casein kinase 2 promotes interaction between Rad17 and the 9-1-1 complex through constitutive phosphorylation of the C-terminal tail of human Rad17, Biochem Biophys Res Commun, 2018, Oct 2;504(2):380-386 29902452 ST Ribeiro,et al. Casein kinase 2 controls the survival of normal thymic and leukemic 污汛 T cells via promotion of AKT signaling, Leukemia, 2017, Jul; 31(7): 1603-1610 27899804 Valentina Gandin,et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly, Nat Commun, 2016, 7: 11127 27040916 Ampofo E,et al. Protein Kinase CK2 Regulates Leukocyte-Endothelial Cell Interactions during Ischemia and Reperfusion in Striated Skin Muscle, Eur Surg Res, 2016, 57(1-2):111-24 27287005 Emmanuel Ampofo,et al. Role of protein kinase CK2 in the dynamic interaction of platelets, leukocytes and endothelial cells during thrombus formation., Thromb Res., 2015, Nov;136(5):996-1006 26381437 Emmanuel Ampofo,et al. Inhibition of protein kinase CK2 suppresses tumor necrosis factor (TNF)-汐-induced leukocyte-endothelial cell interaction., Biochim Biophys Acta., 2015, Oct;1852(10 Pt A):2123-36 26189586 A. Margarida Gomes,et al. Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels, Haematologica, 2014, 99(6): 1062-1068 24561792
A13574	LH 846	CK1 抑制剂	LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α)
A13949 SALE	D4476	CK1 抑制剂	D4476 is a cell-permeant inhibitor of casein kinase 1.
A14101	TTP-22	CK2 抑制剂	TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.
A15069 SALE	DMAT	CK2 抑制剂	DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM.
A15257	TBB	CK2 抑制剂	TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 uM for rat liver and human recombinant CK2 respectively).
A15764 SALE	IC 261	CK1?? and CK1?? 抑制剂	IC 261 is CK1δ and CK1ε inhibitor.
A16234	CX-4945 sodium salt	CK2 抑制剂	CX-4945 sodium salt is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively.
A16235	SR-3029	CK1??/CK1?? 抑制剂	SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor with the IC50 of 97 nM.
A16236	TA-01	CK 抑制剂	TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively).
A11781	PF 670462	Casein kinase 抑制剂	Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.
A10344 SALE	Ellagic acid	-	Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption.
A13584	A-3 Hydrochloride	PKA, PKG, Casein Kinase I and II 抑制剂	A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
A13977	TMCB	CK2/ERK8 抑制剂	MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).

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Stem Cells / Wnt 信号通路

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Stem Cells / Wnt 信号通路

A10258 SALE

A10249

A11048 SALE

A11351

A13095 SALE

A13252 SALE

A11442

A12920

A12418

A16111

A16229

A16349

A13192

A15851 SALE

A15840

A16064 SALE

A16094

A16216

A16217

A16219

A11039 SALE

A10994 SALE

A12362 SALE

A12816 SALE

A12737 SALE

A12707 SALE

A12951 SALE

A13978 SALE

A15229 SALE

A15856

A16198

A16353

A13795

A13986

A15773

A16218 SALE

A11060 SALE

A13574

A13949 SALE

A14101

A15069 SALE

A15257

A15764 SALE

A16234

A16235

A16236

A11781

A10344 SALE

A13584

A13977