Endocrinology / Hormones

产品 1 到 50 共 237个

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  1. Tamoxifen Citrate

    Catalog No. A10885
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    Estrogen receptor 拮抗剂
    Tamoxifen Citrate是哺乳动物甾醇异构酶的选择性和有效抑制剂。 了解更多
  2. Elacestrant

    Catalog No. A12244
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    Estrogen receptor degrader
    Elacestrant (RAD1901) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. 了解更多
  3. Tamoxifen

    Catalog No. A16738
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    selective estrogen receptor modulator (SERM)
    Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. 了解更多
  4. Estetrol

    Catalog No. A21291
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    nuclear estrogen receptor modulator
    Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. 了解更多
  5. GDC-0927 Racemate

    Catalog No. A21507
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    estrogen receptor degrader
    GDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. 了解更多
  6. Fulvestrant R enantiomer

    Catalog No. A21545
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    estrogen receptor antagonist
    Fulvestrant R enantiomer (ICI 182780 R enantiomer; ZD 9238 R enantiomer; ZM 182780 R enantiomer) is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. 了解更多
  7. Pipendoxifene hydrochloride

    Catalog No. A21623
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    estrogen receptor modulators
    Pipendoxifene hydrochloride is a selective estrogen receptor modulators (SERMs). 了解更多
  8. H3B-6545 Hydrochloride

    Catalog No. A21629
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    estrogen receptor covalent antagonist
    H3B-6545 Hydrochloride is an oral, selective estrogen receptor covalent antagonist (SERCA). 了解更多
  9. AZD9496 maleate

    Catalog No. A21726
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    estrogen receptor (ERα) antagonist
    AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD). 了解更多
  10. Enclomiphene citrate

    Catalog No. A21830
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    oestrogen receptor antagonist
    Enclomiphene citrate is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property. 了解更多
  11. 4-Hydroxytamoxifen

    Catalog No. A20955
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    estrogen receptor modulator
    4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM). 了解更多
  12. TAK-875 (Fasiglifam)

    Catalog No. A11018
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    GPR 激动剂
    TAK-875 (Fasiglifam)是一种有效的,选择性的GPR40激动剂。 了解更多
  13. Fulvestrant (Faslodex)

    Catalog No. A10410
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    Aromatase 抑制剂
    Fulvestrant是一种雌激素受体拮抗剂,没有激动剂作用,它通过下调和降解雌激素受体发挥作用。 了解更多
  14. Dienogest

    Catalog No. A10308
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    Dienogest是一种口服抗孕激素,具有抗雄激素活性,因此可以改善雄激素症状。 了解更多
  15. Kaempferol

    Catalog No. A10495
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    ERRα and ERRγ inverse 激动剂
    Kaempferol被发现抑制Ki为0.3-0.5 μM的牛主动脉肌球蛋白轻链激酶,并且还被发现通过新的ERK-NFκB-cMyc-p21途径抑制VEGF表达和体外血管生成。 了解更多
  16. Hexestrol

    Catalog No. A10451
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    Estrogen/progestogen Receptor 激动剂
    Hexestrol是一种致癌的合成雌激素,可抑制微管聚合和带状结构的形成。它是脂质过氧化的抑制剂。 了解更多
  17. Evista (Raloxifene HCl)

    Catalog No. A10375
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    Evista (Raloxifene HCl)是一种口服选择性雌激素受体调节剂(SERM),对骨骼具有雌激素作用,对子宫和乳房具有抗雌激素作用。 了解更多
  18. GSK1292263

    Catalog No. A10439
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    GPR119 激动剂
    GSK-1292263是一种新型GPR119激动剂。 了解更多
  19. LY500307

    Catalog No. A10550
    ERβ 激动剂
    LY500307是一种强效选择性雌激素受体β激动剂,EC50为0.66 nM。 了解更多
  20. Bazedoxifene acetate

    Catalog No. A11665
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    Bazedoxifene Acetate是第三代选择性雌激素受体调节剂(SERM)。 了解更多
  21. Ethisterone

    Catalog No. A11667
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    Ethisterone是孕激素。 了解更多
  22. Clomifene citrate

    Catalog No. A10230
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    Clomifene citrate是一种选择性雌激素受体调节剂,用于诱导排卵。 了解更多
  23. Drospirenone

    Catalog No. A10336
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    Drospirenone是用于避孕药的合成激素。 了解更多
  24. GW9508

    Catalog No. A11965
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    GPR40 抑制剂
    GW 9508是一种可透过细胞的氨基苯基丙酸酯,可作为G蛋白偶联受体(GPCR)GRP40/FFA1受体(EC50?50 nM)的有效选择性激动剂,对家族成员GRP120的活性降低(EC50?3.5μM),GRP41/GRP43(EC50> 50μM),以及一组八种其他游离脂肪酸(FFA)和前列腺素受体。 了解更多
  25. Mifepristone (Mifeprex)

    Catalog No. A10591
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    Mifepristone (Mifeprex)是一种抗氧化剂和糖皮质激素受体拮抗剂,具有抑制NFκB活化的能力,NFκB是一种影响各种粘附分子和几种炎症基因表达的核转录因子。 了解更多
  26. Liquiritigenin

    Catalog No. A12083
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    Liquiritigenin是一种植物来源的高选择性雌激素受体β激动剂。 了解更多
  27. Acolbifene (EM 652, SCH57068)

    Catalog No. A12771
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    estrogen receptor modulator
    Acolbifene (EM 652,SCH57068)是第四代选择性的estrogen receptor拮抗剂,LC50 值为 22±3 nM。用于预防高乳腺癌女性的乳腺癌。 盐酸阿科比芬与体内雌激素受体结合,阻断雌激素对乳房的作用。 它是选择性雌激素受体调节剂(SERM)的一种。 了解更多
  28. Zearalenone

    Catalog No. A13740
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    Zearalenone是通常由镰刀菌属物种产生的一种植物雌激素真菌毒素,被证明是一种细胞毒性化合物,但芦荟结合雌激素受体(ER)(ERβ和ERα的IC50值分别为166和240 nM),并被发现可以刺激转录。两种亚型的活性在1-10 nM之间。 了解更多
  29. Arzoxifene HCl

    Catalog No. A13292
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    Arzoxifene HCl是Arzoxifene的盐酸盐,Arzoxifene是具有抗雌激素特性的合成芳族衍生物。Arzoxifene作为混合的雌激素激动剂/拮抗剂与雌激素受体结合。 了解更多
  30. XCT 790

    Catalog No. A13299
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    ERRα 拮抗剂/inverse 激动剂
    XCT 790是ERRα的强效特异性反向激动剂。 了解更多
  31. Ospemifene

    Catalog No. A14261
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    estrogen receptor modulator
    Ospemifene是一种非激素选择性雌激素受体调节剂(SERM)。 了解更多
  32. IRL-2500

    Catalog No. A13638
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    ETBR 拮抗剂
    IRL-2500是一种有效的选择性ETBR拮抗剂。它显示了对ETB受体的一些选择性(对于ETB和ETA受体,IC50值分别为1.3和94 nM)。 了解更多
  33. Bazedoxifene

    Catalog No. A15019
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    Estrogen modulator
    Bazedoxifene是雌激素受体的第三代选择性调节剂。 了解更多
  34. DY131

    Catalog No. A15071
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    ERRβ and ERRγ 激动剂
    DY131 (GSK 9089)是一种新型的ERRα和ERRβ的选择性激动剂。 了解更多
  35. Toremifene

    Catalog No. A15265
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    Estrogen receptor modulator
    Toremifene是正在开发中的第二代选择性雌激素受体调节剂(SERM),用于预防骨质疏松症。 了解更多
  36. Endoxifen

    Catalog No. A12639
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    Estrogen receptor 拮抗剂
    Endoxifen是他莫昔芬的次生代谢产物。它是负责他莫昔芬在ER阳性乳腺癌中有效性的主要代谢物。Endoxifen Z-isomer抑制hERG, 这种作用具有浓度依赖性, IC50值为1.6μM。 了解更多
  37. AZD9496

    Catalog No. A15822
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    estrogen receptor downregulator and 拮抗剂
    AZD9496是一种有效的生物选择性雌激素受体下调剂和拮抗剂。 了解更多
  38. (E/Z)-4-hydroxy Tamoxifen

    Catalog No. A12532
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    Estrogen receptor 拮抗剂
    (E/Z)-4-hydroxy Tamoxifen是他莫昔芬的活性代谢产物,是一种选择性雌激素受体(ER)调节剂,广泛用于乳腺癌的治疗和化学预防治疗。 了解更多
  39. RAD1901 HCl salt

    Catalog No. A15990
    SERD/SERM
    RAD1901 HCl salt是口服的选择性雌激素受体降解剂(SERD)和选择性雌激素受体调节剂(SERM),具有潜在的抗肿瘤活性和类似雌激素的活性。 了解更多
  40. GDC-0810 (Brilanestrant)

    Catalog No. A15958
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    Estrogen receptor degrader
    GDC-0810 (Brilanestrant)是一种口服可生物利用的选择性雌激素受体降解剂(SERD),在耐他莫昔芬的乳腺癌异种移植物中表现出强大的活性。 了解更多
  41. Endoxifen E-isomer hydrochloride

    Catalog No. A16343
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    Endoxifen E-isomer hydrochloride是他莫昔芬的代谢产物和有效的选择性雌激素反应调节剂(SERM)。 了解更多
  42. GSK4716

    Catalog No. A16956
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    ERRβ & ERRγ 激动剂
    GSK4716是与雌激素相关的受体ERRβ/γ激动剂,对ERRα,ERα和ERβ具有最小的活性。 了解更多
  43. (R)-Equol

    Catalog No. A16986
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    Estrogen receptor 激动剂
    (R)-Equol是ER&alpha和ER&beta的激动剂,Kis分别为27.4和15.4 nM。 了解更多
  44. Lasofoxifene Tartrate

    Catalog No. A18097
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    selective Estrogen receptor modulator
    Lasofoxifene tartrate is a third-generation selective estrogen receptor modulator. 了解更多
  45. H3B-6545

    Catalog No. A20100
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    Estrogen receptor antagonist
    H3B-6545 is an oral, selective estrogen receptor covalent antagonist (SERCA). 了解更多
  46. PROTAC ERRα ligand 2

    Catalog No. A18939
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    ERRα inverse agonist
    PROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). 了解更多
  47. PROTAC ERRα Degrader-1

    Catalog No. A18910
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    ERRα Degrader
    PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多
  48. PROTAC ER Degrader-3

    Catalog No. A18519
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    PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多
  49. MK-6913

    Catalog No. A12311
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    Estrogen receptor β agonist
    Tetrahydrofluoroene 52 is a potent and selective estrogen receptor β agonist. 了解更多
  50. Asoprisnil

    Catalog No. A19030
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    Progesterone receptor modulator
    Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human. 了解更多

产品 1 到 50 共 237个

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