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Endocrinology / Hormones | 内分泌 / 荷尔蒙



产品 1 到 50 共 168个

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Catalog No. Product Name Application Product Information
A11018 SALE

TAK-875 (Fasiglifam)

GPR 激动剂
TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist.
A10410 SALE

Fulvestrant (Faslodex)

Aromatase 抑制剂
Fulvestrant is an estrogen receptor antagonist with no agonist effects, which works both by down-regulating and by degrading the estrogen receptor.
A10308 SALE

Dienogest

-
Dienogest is an oral progestin that has antiandrogenic activity and as a result can improve androgenic symptoms.
A10495 SALE

Kaempferol

ERR?? and ERR?? inverse 激动剂
Kaempferol is found to inhibit bovine aorta myosin light chain kinase with a Ki of 0.3-0.5 microM and also is found to inhibit VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway.
A10451 SALE

Hexestrol

Estrogen/progestogen Receptor 激动剂
Hexestrol is a carcinogenic synthetic estrogen that inhibits microtubule polymerization and the formation of ribbon structures. It is an inhibitor of lipid peroxidation.
A10375 SALE

Evista (Raloxifene HCl)

-
Raloxifene is an oral selective estrogen receptor modulator (SERM) that has estrogenic actions on bone and anti-estrogenic actions on the uterus and breast. It is used in the prevention of osteoporosis in postmenopausal women.
A10439 SALE

GSK1292263

GPR119 激动剂
GSK-1292263 is a novel GPR119 agonist.
A10550

LY500307

ER?? 激动剂
LY500307 is a potent, selective estrogen receptor beta agonist with an EC50 of 0.66 nM.
A11665

Bazedoxifene acetate

-
Bazedoxifene is a third generation selective estrogen receptor modulator (SERM). Bazedoxifene acetate significantly prevents bone mass loss at 20 mg/day in healthy postmenopausal women with normal or low bone mineral density.
A11667 SALE

Ethisterone

-
Ethisterone is a progestogen hormone.
A10230 SALE

Clomifene citrate

-
Clomifene inhibits estrogen receptors in hypothalamus, inhibiting negative feedback of estrogen on gonadotropin release, leading to up-regulation of the hypothalamic-Cpituitary-Cadrenal axis.
A10336

Drospirenone

-
Drospirenone is a synthetic hormone used in birth control pills.
A11965

GW9508

GPR40 抑制剂
GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ?50 nM) with reduced activity towards family members GRP120 (EC50 ?3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors.
A10591

Mifepristone (Mifeprex)

-
Mifepristone, an antioxidant and glucocorticoid receptor antagonist, demonstrates the ability to suppress activation of NFκB, a nuclear transcription factor that affects the expression of various adhesion molecules and several inflammatory genes.
A12083

Liquiritigenin

-
Liquiritigenin is a plant-derived highly selective estrogen receptor ?? agonist
A12771

Acolbifene (EM 652, SCH57068)

estrogen receptor modulator
acolbifene is a substance being studied in the prevention of breast cancer in women at high risk of breast cancer. Acolbifene hydrochloride binds to estrogen receptors in the body and blocks the effects of estrogen in the breast. It is a type of selective estrogen receptor modulator (SERM).
A13740 SALE

Zearalenone

-
Zearalenone is a phytoestrogenic mycotoxin usually produced by Fusarium species, is shown to be a cytotoxic compound, but alos binds to the estrogen receptor (ER) (IC50 values are 166 and 240 nM for ERβ and ERα respectively) and was found to stimulate the transcriptional activity of both subtypes at concentrations between 1 - 10 nM.
A13292

Arzoxifene HCl

-
Arzoxifene HCl is the hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist.
A13299 SALE

XCT 790

ERR?? 拮抗剂/inverse 激动剂
XCT 790 is a potent and specific inverse agonist of ERRα.
A14261

Ospemifene

estrogen receptor modulator
Ospemifene is a non-hormonal selective estrogen receptor modulator (SERM).
A13638

IRL-2500

ETBR 拮抗剂
IRL-2500 is a potent, selective ETBR antagonist. It shows some selectivity for ETB receptors (IC50 values are 1.3 and 94 nM for ETB and ETA receptors respectively).
A15019

Bazedoxifene

Estrogen modulator
Bazedoxifene is a third generation selective modulator of estrogen receptor.
A15071

DY131

ERR?? and ERR?? 激动剂
DY131(GSK 9089) is a novel selective agonist of ERRα and ERRβ.
A15265

Toremifene

Estrogen receptor modulator
Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
A12639 SALE

Endoxifen

Estrogen receptor 拮抗剂
Endoxifen is a secondary metabolite of tamoxifen. It is a primary metabolite responsible for the effectiveness of tamoxifen in ER-positive breast cancer.
A15822

AZD9496

estrogen receptor downregulator and 拮抗剂
AZD9496 is a potent and orally bioavailable selective estrogen receptor downregulator and antagonist.
A12532

4-Hydroxytamoxifen

Estrogen receptor 拮抗剂
4-Hydroxytamoxifen is the active metabolite of tamoxifen and a selective estrogen receptor (ER) modulator that is widely used in the therapeutic and chemopreventive treatment of breast cancer.
A15990

RAD1901 HCl salt

SERD/SERM
RAD1901 is an orally available, selective estrogen receptor degrader (SERD) and selective estrogen receptor modulator (SERM), with potential antineoplastic and estrogen-like activities.
A15958

GDC-0810

Estrogen receptor degrader
GDC-0810 an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts.
A16343

Endoxifen E-isomer hydrochloride

-
Endoxifen (E-isomer hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM).
A10885 SALE

Tamoxifen Citrate

Estrogen receptor 拮抗剂
Tamoxifen Citrateis a selective and potent inhibitor of mammalian sterol isomerase.
A10529 SALE

Levonorgestrel

-
Levonorgestrelis a synthetic progesterone analog; binds to the progesterone receptor (relative binding affinities are < 0.02, 7.5, 17, 58 and 323 % for estrogen receptors, glucocorticoid receptors, mineralocorticoid receptors, androgen receptors and progesterone receptors respectively).
A10563 SALE

Megestrol Acetate

-
Megestrol Acetate is a progesterone derivative with antineoplastic properties
A14130

Lonaprisan

progesterone receptor 拮抗剂
Lonaprisan is an orally bioavailable pentafluoroethyl derivative of a mifepristone-related steroid with antiprogestagenic activity.
A15184

Nestoron

progesterone receptor 激动剂
Nestoron is a 19-norprogesterone derivative and steroidal progestin which is used as a hormonal contraceptive; a high-affinity agonist of the progesterone receptor.
A15256

Tanaproget

Progesterone receptor 激动剂
Tanaproget is a novel nonsteroidal progesterone receptor agonist which can bind to the PR from various species with a higher relative affinity than reference steroidal progestins.
A15780

ACT-129968 (Setipiprant)

CRTH2 拮抗剂
ACT-129968 is a potent and selective CRTH2 antagonist.
A15860

17-Hydroxyprogesterone

-
17-Hydroxyprogesterone is an endogenous progestogen as well as chemical intermediate in the biosynthesis of other steroid hormones, including the corticosteroids and the androgens and the estrogens.
A11625

Medroxyprogesterone Acetate

progesterone receptor 激动剂
Medroxyprogesterone acetate is a progestin, a synthetic variant of the human hormone progesterone and a potent progesterone receptor agonist.
A16117

Etonogestrel

-
Etonogestrel is a steroidal progestin used in hormonal contraceptives, most notably the subdermal implant Nexplanon and the vaginal ring NuvaRing.
A16143

Hydroxyprogesterone caproate

-
Hydroxyprogesterone caproate is a synthetic, steroidal progestin; an ester derivative of 17??-hydroxyprogesterone formed from caproic acid.
A16173

Desogestrel

-
Desogestrel is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
A15164

MK-0773

Androgen receptor modulator
MK-0773, one of selective androgen receptor modulators (SARMs), is a 4-aza-steroid that exhibited tissue selectivity in humans (IC50= 6.6 nM).
A15797 SALE

ODM-201

Androgen receptor 拮抗剂
ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.
A15814

EPI-001

Androgen Receptor 拮抗剂
EPI-001 is an antagonist of the androgen receptor (AR) that acts by binding covalently to the N-terminal domain (NTD) of the AR and blocking protein-protein interactions required for transcriptional activity of the AR and its splice variants (IC50 for inhibition of AR NTD transactivation ?? 6 ?M)
A10402 SALE

Flutamide

Androgen receptor 拮抗剂
Flutamide is an antiandrogen drug, with its active metablolite binding at androgen receptor with Ki values of 55 nM, and primarily used to treat prostate cancer.
A10253 SALE

Ostarine (MK-2866, GTx-024)

Androgen Receptor Modulators
Ostarine is an androgen receptor modulator (SARM)
A10562 SALE

MDV3100

Androgen receptor 拮抗剂
MDV3100 is androgen-receptor inhibitor. Highly recommended inhibitor in AR research.
A10008

(R)-Bicalutamide

Androgen Receptor 拮抗剂
(R)-Bicalutamide is an active competitive non-steroidal androgen receptor antagonist with an IC50 of 0.17 μM for MDA 453 cells.
A10142 SALE

Bicalutamide (Casodex)

Androgen Receptor 拮抗剂
Bicalutamide is an oral non-steroidal anti-androgen used in the treatment of prostate cancer and hirsutism.

产品 1 到 50 共 168个

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