GPCR / G Protein

产品 1 到 50 共 868个

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  1. SB 258585 HCl

    Catalog No. A14026
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    5-HT6 serotonin receptor 拮抗剂
    SB 258585 hydrochloride是一种选择性和有效的SR-6拮抗剂。该化合物显示出比其他5-羟色胺受体亚型高160倍的选择性。 了解更多
  2. Granisetron

    Catalog No. A15096
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    5-HT3 拮抗剂
    Granisetron是一种5-羟色胺5-HT3受体拮抗剂,可作为止吐药来治疗化疗后的恶心和呕吐。 了解更多
  3. LY 344864

    Catalog No. A15148
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    5HT1F 激动剂
    LY344864是一种选择性受体激动剂,对最近克隆的5-HT1F受体的亲和力为6 nM(Ki)。 了解更多
  4. WAY-100635 maleate salt

    Catalog No. A15282
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    5HT1A 拮抗剂
    WAY-100635 maleate salt是一种有效的、选择性的5-羟色胺1A拮抗剂,对5-HT的IC50为0.95-0.12 nM。 了解更多
  5. Piboserod

    Catalog No. A15542
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    5-HT4 receptor 拮抗剂
    Piboserod是一种选择性的5-HT(4)受体拮抗剂。 了解更多
  6. Ricasetron

    Catalog No. A15499
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    5-HT3 receptor 拮抗剂
    Ricasetron是在5-羟色胺5-HT3受体上充当选择性拮抗剂的药物。 了解更多
  7. LY278584

    Catalog No. A15500
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    5-HT3 拮抗剂
    LY278584是5-HT3受体的有效选择性拮抗剂。LY278584是研究大鼠脑内5-HT3受体定位的有用配体。 了解更多
  8. Lerisetron

    Catalog No. A15501
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    5HT3 receptor 拮抗剂
    Lerisetron是具有止吐活性的3型血清素(5-HT3)受体拮抗剂。 了解更多
  9. SB271046 HCl

    Catalog No. A15438
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    5-HT Receptor 拮抗剂
    SB271046 hydrochloride是一种有效的,选择性的5-HT6受体拮抗剂,pKi为8.9,与其他5-HT受体亚型相比,选择性高200倍。 了解更多
  10. Pimavanserin (ACP-103)

    Catalog No. A14434
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    5-HT2A receptor 激动剂
    Pimavanserin (ACP-103)是一种有效的选择性5-HT2A受体反向激动剂,在基于细胞的功能测定中,平均pIC50为8.7。 了解更多
  11. Ketanserin tartrate

    Catalog No. A13664
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    5HT2A 拮抗剂
    Ketanserin tartrate是一种选择性的5-HT receptor拮抗剂。Ketanserin tartrate 也抑制 hERG 电流 (IhERG),IC50 为 0.11 μM。 了解更多
  12. WAY 181187

    Catalog No. A14163
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    5-HT6 激动剂
    WAY 181187是一种高亲和力且选择性的5-HT6激动剂,Ki值为2.2 nM。 了解更多
  13. GSK163090

    Catalog No. A15838
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    5-HT1A/B/D receptor 拮抗剂
    GSK163090是一种有效的,选择性的,活性的5-HT1A/B/D受体拮抗剂,对于5-HT1A/B/D和多巴胺D2/D3,pKi分别为9.4/8.5/9.7和6.3/6.7。 了解更多
  14. Flopropione

    Catalog No. A16550
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    5-HT1A receptor antagonist/COMT inhibitor
    Flopropione是5-HT1A受体拮抗剂,也是儿茶酚-邻甲基转移酶(COMT)抑制剂。 了解更多
  15. MHP 133

    Catalog No. A20058
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    AChE /M1/M2/5HT4/I2 inhibitor
    MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors. 了解更多
  16. CP-809101

    Catalog No. A12481
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    5-HT2C receptor agonist
    CP-809101 is a potent and selective 5-HT2C receptor agonist with pEC50 of 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors respectively. 了解更多
  17. Donitriptan

    Catalog No. A13145
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    5-HT1B/1D receptors agonist
    Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively. 了解更多
  18. Deramciclane

    Catalog No. A13011
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    5-HT2A and 5-HT2C receptors antagonist
    Deramciclane has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist. 了解更多
  19. YM348

    Catalog No. A12290
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    5-HT2C receptor agonist
    YM348 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM). 了解更多
  20. AP521

    Catalog No. A12280
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    human 5-HT1A receptor agonist
    AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM. 了解更多
  21. lumateperone Tosylate

    Catalog No. A12279
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    5-HT2A receptor antagonist
    Lumateperone Tosylate is a 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a SERT blocker (Ki = 61 nM). 了解更多
  22. 5-HT4 antagonist 1

    Catalog No. A12268
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    5-HT4 receptor antagonist
    5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. 了解更多
  23. PRX933 hydrochloride

    Catalog No. A12261
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    5-HT2c receptor agonist
    PRX933 hydrochloride is a 5-HT2c receptor agonist extracted from patent WO 2014140631 A1. 了解更多
  24. Ziprasidone hydrochloride monohydrate

    Catalog No. A11008
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    5-HT (serotonin) and dopamine receptor antagonist
    Ziprasidone hydrochloride monohydrate (CP 88059 hydrochloride monohydrate) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. 了解更多
  25. Pancopride

    Catalog No. A12967
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    5-HT3 receptor antagonist
    Pancopride is a new potent and selective 5-HT3 receptor antagonist. 了解更多
  26. Lesopitron dihydrochloride

    Catalog No. A12950
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    5-HT1A receptor agonist
    Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes. 了解更多
  27. SB 271046 Hydrochloride

    Catalog No. A11573
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    5-HT6 receptor antagonist
    SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9. 了解更多
  28. WAY-100635 Maleate

    Catalog No. A16787
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    5-HT1A receptor antagonist
    WAY-100635 maleate is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. 了解更多
  29. Ziprasidone hydrochloride

    Catalog No. A16790
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    5-HT (serotonin)/dopamine receptor antagonist
    Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. 了解更多
  30. Sarpogrelate hydrochloride

    Catalog No. A17295
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    5-HT2 antagonist
    Sarpogrelate hydrochloride (MCI-9042), a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD. 了解更多
  31. RU 24969

    Catalog No. A20857
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    5-HT1A/5-HT1B receptors agonist
    RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors. 了解更多
  32. Befiradol

    Catalog No. A21189
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    5-HT1A receptor agonist
    Befiradol (NLX-112) is a selective 5-HT1A receptor agonist. 了解更多
  33. RS 127445

    Catalog No. A21256
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    5-HT2B receptor antagonist
    RS 127445 is a novel high affinity, selective 5-HT2B receptor antagonist with pKi of 9.5. 了解更多
  34. Vortioxetine

    Catalog No. A21266
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    5-HT1A/5-HT1B/5-HT3A/5-HT7 receptor/SERT inhibitor
    Vortioxetine is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. 了解更多
  35. WAY 163909

    Catalog No. A21282
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    5-HT(2C) receptor agonist
    WAY 163909 is a potent and selective 5-HT(2C) receptor agonist with a Ki of 10.5??1.1 nM. 了解更多
  36. SB 242084 hydrochloride

    Catalog No. A21349
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    5-HT2C receptor antagonist
    SB 242084 hydrochloride is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. 了解更多
  37. Masupirdine mesylate

    Catalog No. A21409
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    5-HT6 receptor antagonist
    Masupirdine mesylate (SUVN-502 mesylate) is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). 了解更多
  38. Nelotanserin

    Catalog No. A21506
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    5-HT2A inverse agonist
    Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively. 了解更多
  39. Lasmiditan hydrochloride

    Catalog No. A21523
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    5-HT1F receptor agonist
    Lasmiditan hydrochloride is a high-affinity, highly selective 5-HT1F receptor agonist (Ki=2.1 nM), compared with Ki of 1043 nM and 1357 nM at the 5-HT(1B) and 5-HT(1D) receptors, respectively. 了解更多
  40. SB 242084

    Catalog No. A21715
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    5-HT2C receptor antagonist
    SB 242084 is a 5-HT2C receptor antagonist(pKi=9.0) that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. 了解更多
  41. LY 344864 S-enantiomer

    Catalog No. A21742
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    5-HT1F receptor agonist
    LY 344864 S-enantiomer is the S-enantiomer of LY344864. LY344864 is a 5-HT1F receptor agonist. 了解更多
  42. LY 344864 hydrochloride

    Catalog No. A21748
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    5-HT1F agonist
    LY 344864 hydrochloride is a selective 5-HT1F agonist with a Ki of 6 nM. 了解更多
  43. Vilazodone D8

    Catalog No. A21876
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    SSR inhibitor / 5-HT1A receptor partial agonist
    Vilazodone D8 is the a deuterium labeled vilazodone, which is a combined serotonin specific reuptake inhibitor (SSRI) and 5-HT1A receptor partial agonist. 了解更多
  44. SB-269970 hydrochloride

    Catalog No. A21889
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    5-HT7 receptor antagonist
    SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors. 了解更多
  45. SB-224289 hydrochloride

    Catalog No. A21920
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    5-HT1B receptor antagonist
    SB-224289 hydrochloride is a selective 5-HT1B receptor antagonist, with anxiolytic effect. 了解更多
  46. Ritanserin

    Catalog No. A21976
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    5-HT2 receptor antagonist
    Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors. 了解更多
  47. Eplivanserin mixture

    Catalog No. A21987
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    serotonin reuptake inhibitor/5-HT2A receptor antagonist
    Eplivanserin mixture is a selective serotonin reuptake inhibitor and a 5-HT2A receptor antagonist, extracted from patent WO 2005/002578 A1. 了解更多
  48. Ziprasidone D8

    Catalog No. A21989
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    5-HT / dopamine receptor antagonist
    Ziprasidone D8 is deuterium labeled Ziprasidone, which is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity. 了解更多
  49. Aripiprazole (D8)

    Catalog No. A22004
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    human 5-HT1A receptor partial agonist
    Aripiprazole D8 (OPC-14597 D8) is the deuterium labeled Aripiprazole, which is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM. 了解更多
  50. Mosapride citrate

    Catalog No. A10607
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    5-HT4-receptor 激动剂
    Mosapride citrate起5-HT4受体激动剂和5-HT3受体拮抗剂的作用。 了解更多

产品 1 到 50 共 868个

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