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G 蛋白偶联受体 / G 蛋白

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Catalog No. Product Name Application Product Information

SB 258585 HCl

5-HT6 serotonin receptor 拮抗剂
SB 258585 hydrochloride has been found to be a selective and potent SR-6 antagonist. This compound displays more than a 160-fold selectivity over other serotonin receptor subtypes.


5-HT3 拮抗剂
Granisetron is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.

LY 344864

5HT1F 激动剂
LY344864 is a selective receptor agonist with an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
A15282 SALE

WAY-100635 maleate salt

5HT1A 拮抗剂
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 - 0.12 nM for 5-HT.


5-HT4 receptor 拮抗剂
Piboserod is a selective 5-HT(4) receptor antagonist.


5-HT3 receptor 拮抗剂
Ricasetron is a drug which acts as a selective antagonist at the serotonin 5-HT3 receptor.


5-HT3 拮抗剂
LY278584 is a potent and selective antagonist of 5-HT3 receptors. LY278584 is a useful ligand for studying the localization of 5-HT3 receptors in rat brain


5HT3 receptor 拮抗剂
Lerisetron is a serotonin type 3 (5-HT3) receptor antagonist with antiemetic activity.

SB271046 HCl

5-HT Receptor 拮抗剂
SB271046 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9, exhibits 200-fold greater selectivity over other 5-HT receptor subtypes.
A14434 SALE

Pimavanserin (ACP-103)

5-HT2A receptor 激动剂
Pimavanserin is a potent and selective 5-HT2A receptor inverse agonist with mean pIC50 of with 8.7 in the cell-based functional assay.

Ketanserin tartrate

5HT2A 拮抗剂
Ketanserin tartrate is a salt of Ketanserin. Ketanserin is reported to have a high affinity for multiple G protein-coupled receptors, such as serotonin receptors.

WAY 181187

5-HT6 激动剂
WAY 181187 is a high affinity and selective 5-HT6 agonist with Ki value of 2.2 nM.


5-HT1A/B/D receptor 拮抗剂
GSK163090 is a potent, selective, and orally active 5-HT1A/B/D receptor antagonist with pKi of 9.4/8.5/9.7, and 6.3/6.7 for 5-HT1A/B/D, and dopamine D2/D3, respectively.
A10607 SALE

Mosapride citrate

5-HT4-receptor 激动剂
Mosapride citrate acts as 5-HT4 receptor agonist and 5-HT3 receptor antagonist.

Tianeptine sodium

5-HT Receptor 激动剂
Tianeptine sodium is a selective serotonin reuptake enhancer (SSRE) in vitro and in vivo.


5-HT Receptor 拮抗剂
Agomelatine is a melatonergic agonist (MT1 and MT2 receptors) and 5-HT2C antagonist.


5-HT Receptor 拮抗剂
LY310762 is a 5-HT1D-preferring receptor antagonist (EC50 = 31 nM).
A10017 SALE

5-hydroxytryptophan (5-HTP)

5-Hydroxytryptophan (5-HTP) is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from tryptophan.
A11165 SALE


5-HT2B receptor 拮抗剂

RS-127445 is a potent and selective antagonist at the serotonin 5-HT2B receptor, with around 1000x selectivity over the closely related 5-HT2A and 5-HT2C receptors.



5-HT1D receptor 拮抗剂

BRL-15572 is a selective h5-HT1D antagonist, displaying 60-fold selectivity over h5-HT1B, and exhibiting little or no affinity for a range of other receptor types.

A11182 SALE


5HT1A 拮抗剂

WAY-100635 was originally believed to act as a selective 5-HT1A receptor antagonist, but subsequent research showed that it also acts as potent full agonist at the D4 receptor.

A11208 SALE

BMY 7378

5-HT1A 激动剂
BMY 7378 is a 5-HT1A partial agonist and high affinity α1D adrenoceptor antagonist.

Naftopidil 2HCl

5-HT1A and ??1-adrenergic receptor 拮抗剂
Naftopidil 2HCl is a selective 5-HT1A and α1-adrenergic receptor antagonist with IC50 of 0.1 μM and 0.2 μM, respectively.

Puerarin (Kakonein)

5-HT2C receptor 拮抗剂
Puerarin is one of several known isoflavones. Puerarin is a 5-HT2C receptor and benzodiazepine site antagonist. Puerarin is being investigated as a self-microemulsifying drug delivery system.
A10797 SALE

Risperidone (Risperdal)

Risperidone(Risperdal) is an atypical antipsychotic used to treat schizophrenia (including adolescent schizophrenia), schizoaffective disorder, the mixed and manic states associated with bipolar disorder, and irritability in children with autism.

Tropisetron (ICS 205930)

5-HT3 拮抗剂
Tropisetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy.


Serotonin reuptake 抑制剂
Vilazodone acts as a serotonin reuptake inhibitor (IC50 = 0.5 nM) and 5-HT1A receptor partial agonist (IC50 = 0.2 nM; IA = ~60-70%).
A11705 SALE


Duloxetine is a serotonin-norepinephrine reuptake inhibitor (SNRI). It is effective for major depressive disorder and generalized anxiety disorder (GAD).
A11771 SALE


5-HT Receptor 激动剂
Prucalopride is a selective, high affinity 5-HT4 receptor agonist which targets the impaired motility associated with chronic constipation, thus normalising bowel movements.
A11310 SALE


5-HT3 拮抗剂
Alosetron is a 5-HT3 antagonist that an antagonist action on the 5-HT3 receptors of the enteric nervous system of the gastrointestinal tract.


5-HT1 receptor
Naratriptan is a selective 5-HT1 receptor subtype agonist.
A11925 SALE

SB269970 HCl

5-HT7 receptor 拮抗剂
SB269970 is a potent and selective 5-HT7 receptor antagonist.

Ondansetron (Zofran)

Ondansetron is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic (to treat nausea and vomiting). Ondansetron reduces the activity of the vagus nerve, which deactivates the vomiting center in the medulla oblongata, and also blocks serotonin receptors in the chemoreceptor trigger zone.


Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA) . Structurally, mirtazapine can also be classified as a tetracyclic antidepressant (TeCA).
A11703 SALE

Trazodone HCl

Trazodone is an antidepressant of the serotonin antagonist and reuptake inhibitor (SARI) class. It is a phenylpiperazine compound. Trazodone also has anti-anxiety (anxiolytic) and sleep-inducing (hypnotic) effects.

Urapidil hydrochloride

Urapidil hydrochloride is an α1-adrenoceptor antagonist, 5-HT1A serotonin receptor partial agonist and anti-hypertensive.

Duloxetine HCl

Duloxetine Hydrochloride is a dual serotonin and norepinephrine reuptake inhibitor (SNRI) that is used in the treatment of stress urinary incontinence, as well as depression.
A11743 SALE

Tegaserod maleate

Tegaserod functions as a motility stimulant, achieving its desired therapeutic effects through activation of the 5-HT4 receptors of the enteric nervous system in the gastrointestinal tract. It also stimulates gastrointestinal motility and the peristaltic reflex, and allegedly reduces abdominal pain. Additionally, tegaserod is a 5-HT2B receptor antagonist.
A10091 SALE

Asenapine maleate

H1 拮抗剂
Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors.
A10231 SALE

Clomipramine HCl

5-HT Receptor 激动剂
Clomipramine is a blocker of the following transporters:Serotonin transporter (SERT) (Ki = 0.14 nM),Norepinephrine transporter (NET) (Ki = 54 nM),Dopamine transporter (DAT) (Ki = 3,020 nM),Glycine transporter (GlyT/LeuT).
A10287 SALE

Dapoxetine hydrochloride

Dapoxetine works by inhibiting serotonin transporter, increasing serotonins action at the post synaptic cleft, and as a consequence promoting ejaculatory delay.
A10222 SALE

Citalopram Hydrobromide

Citalopram is a selective inhibitor of ST (5-hydroxytryptamine/serotonin transporter) and therefore is a potent and selective serotonin reuptake inhibitor.
A10497 SALE

Ketanserin (Vulketan Gel)

5-HT2A serotonin receptor 拮抗剂
Ketanserin (Vulketan Gel) is specific 5-HT2A serotonin receptor antagonist with a Ki of 2.5 nM for rat and human 5-HT2A.
A10437 SALE

Granisetron Hydrochloride

5-HT3 receptor 拮抗剂
Granisetron HCl is a serotonin 5-HT3 receptor antagonist
A11799 SALE

Almotriptan malate (Axert)

5-HT Receptor 激动剂
Almotriptan malate (Axert) is a selective 5-hydroxytryptamine1B/1D (5-HT1B/1D) receptor agonist, used for the treatment of Migraine attacks in adults.
A11801 SALE

Aripiprazole (Abilify)

5-HT1A receptor 激动剂
Aripiprazole is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.

Mianserin hydrochloride

5-HT2/5-HT1 拮抗剂
Mianserin hydrochloride is a 5-HT2/5-HT1 antagonist. Has moderate affinity for 5-ht6 Non-selective 5-HT2 receptor antagonist. Has moderate affinity for 5-HT6. Antidepressant.
A11873 SALE


Lamotrigine is a novel anticonvulsant drug for inhibition of 5-HT with IC50 of 240 μM and 474 μM in human platelets and rat brain synaptosomes, and also is a sodium channel blocker.
A11418 SALE

Eletriptan hydrobromide

5-HT1B/1D receptor 激动剂
Eletriptan hydrobromide is a selective SR-1B/SR-1D agonist.

Vortioxetine (Lu AA21004) hydrobromide

5-HT Receptor modulator
Lu-AA21004 is an oral multimodal serotonergic agent, inhibits 5-HT(1A), 5-HT(1B), 5-HT(3A), 5-HT(7) and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.

产品 1 到 50 共 529个

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