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跨膜转运 / 离子通道



产品 1 到 50 共 228个

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Catalog No. Product Name Application Product Information
A11156 SALE

Brefeldin A

Protein translocation 抑制剂
Brefeldin A blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange.
A11408

PF 3716556

ATPase 拮抗剂
PF 3716556 is H+,K+-ATPase inhibitor (pIC50 = 6 in human recombinant ion-leaky assays).
A10854 SALE

Sodium orthovanadate

-
Sodium orthovanadate is the chemical compound Na3VO4. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
A10086 SALE

Artemisinin

-
Artemisinin and its derivatives are a group of drugs that possess the most rapid action of all current drugs against Plasmodium falciparum malaria.
A10213 SALE

Ciclopirox

-
Ciclopirox is currently being investigated as an alternative treatment to ketoconazole for seborrhoeic dermatitis as it suppresses growth of the yeast Malassezia furfur.It acts by inhibiting the membrane transfer system by interrupting the Na+ K+ ATPase.
A11696

Pantoprazole (Protonix)

-
Pantoprazole is a proton pump inhibitor drug that inhibits gastric acid secretion.
A11961

Bafilomycin A1

ATPase 抑制剂
Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes in rat hepatoma cell line, H-4-II-E cells.
A12022 SALE

Bufalin

-
Bufalin is a cardiotonic steroid originally isolated from the Chinese toad venom.
A12023

Resibufogenin

-
Resibufogenin is a specific Na+/K+-ATPase inhibitor.
A12024

Bufotalin

-
Bufotalin is a less potent Na+/K+-ATPase inhibitor than other bufadienolides. Potent immunosuppressor.
A12032

Cinobufagin

-
Cinobufagin is a specific Na+/K+-ATPase inhibitor. About as active as ouabain
A12755

Ouabain

a-K-ATPase 抑制剂
Ouabain is a selective Na+, K+-ATPase inhibitor.
A10669

Oligomycin A

ATPase 抑制剂
Oligomycin A is a mitochondrial ATPase inhibitor. Oligomycin A inhibits ATP5 (mitochondrial ATPases, F1F0) bound to the cell membrane.
A10672 SALE

Omeprazole

ATPase 抑制剂s
Omeprazole is a cell-permeable, selective proton pump inhibitor.
A13041

PST-2744 (Istaroxime)

-
Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
A13283 SALE

Rostafuroxin (PST-2238)

Na+/K+ ATPase modulator
Rostafuroxin (PST-2238) is an ouabain-inhibitor counteracting specific forms of hypertension.
A13647 SALE

(-)-Blebbistcitin

myosin II 抑制剂
Blebbistatin, a myosin II inhibitor, is photoinactivated by blue light.
A14308 SALE

BTB06584

F1 Fo-ATPase 抑制剂
BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase.
A13912 SALE

Melittin

Na+/K+ ATPase 抑制剂
Melittin is a Na+/K+ ATPase inhibitor. It inhibits Gs and stimulates Gi activity. It inhibits protein kinase C and cAMP-dependent protein kinases.
A14000

Oligomycin

ATP synthase 抑制剂
Oligomycin is a macrolide that acts as a specific inhibitor of the mitochondrial ATP-synthase and blocks oxidative phosphorylation.
A14002

Cyclopiazonic Acid

SERCA 抑制剂
Cyclopiazonic acid is an inhibitor of SERCA (endoplasmic reticulum Ca2+-ATPase) which induces the release of intracellular stored Ca2+, without increasing IP3 levels.
A14007

Thapsigargin

SERCA ATPase 抑制剂
Thapsigargin is a cell-permeable sesquiterpene lactone found in the roots of Thapsia garganica. It is a tumor promoter and induces the release of intracellular stored Ca2+ without hydrolysis of inositolphospholipids via inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA, IC50=30 nM).
A14875

Glucagon (19-29), human

Ca 2+ /Mg 2+ -ATPase 抑制剂
Glucagon (19-29) (human) is a potent Ca 2+ /Mg 2+ -ATPase inhibitor.
A10758 SALE

PTC124 (Ataluren)

CFTR 抑制剂
PTC124 also known as Ataluren is CFTR-G542X nonsense allele inhibitor.
A10985 SALE

VX-770 (Ivacaftor)

CFTR activator
VX-770 (Ivacaftor) is known as a CFTR potentiator.
A10986 SALE

VX-809 (Lumacaftor)

CFTR modulator
VX-809 is the second investigational oral candidate compound for the treatment of cystic fibrosis (CF).
A12519

VX-661

CFTR corrector
VX-661 is another cystic fibrosis transmembrane conductance regulator (CFTR) corrector in development for the treatment of cystic fibrosis.
A13511

IOWH032

CFTR 抑制剂
IOWH032 is a CFTR inhibitor.
A13723 SALE

CFTR-Inhibitor-II

CFTR 抑制剂
CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 uM).
A13000 SALE

PPQ-102

CFTR chloride channel 抑制剂
PPQ-102 is a compound that targets intracellular nucleotide binding domain(s) of CFTR and inhibits CFTR- mediated chloride current in a voltage-dependent and reversible manner.
A10675 SALE

Oridonin (Isodonol)

CFTR 抑制剂
Oridonin (Isodonol), an entkaurane diterpenoid isolated from Rabdosia rubescens, is an important traditional Chinese herbal remedy.
A12897 SALE

CFTRinh-172

CFTR 抑制剂
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor
A15843 SALE

KM 11060

F508del-CFTR trafficking corrector
KM 11060 corrects F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane (~75%) and Inhibits PDE5 activity
A11140

NPS-2143 (SB-262470)

CaR 拮抗剂
NPS-2143 is a selective Ca2+-sensing receptor antagonist, shown to block increases in cytoplasmic Ca2+ concentrations elicited by human Ca2+ receptors expressed in HEK293 cells with an IC50 of 43 nM.
A10921

Tetrandrine (Fanchinine)

Calcium Channel 抑制剂
Tetrandrine is a calcium channel blocker. It inhibits the degranulation of mast cells.Tetrandrine has anti-inflammatory and anti-fibrogenic actions, which make tetrandrine and related compounds potentially useful in the treatment of lung silicosis, liver cirrhosis, and rheumatoid arthritis.
A11405

Astragaloside A

Ca2+ signaling modulator
Astragaloside A is a novel regulator of HIF-1α and angiogenesis through the PI3K/Akt pathway in HUVECs that are exposed to hypoxia.
A11206 SALE

CK-1827452 (Omecamtiv mecarbil)

Myosin activator
CK-1827452 is a selective cardiac specific myosin activator.
A10219 SALE

AMG-073 HCl (Cinacalcet HCl)

CaSR activator
AMG-073 HCl (Cinacalcet HCl) represents a new class of compounds for the treatment of hyperparathyroidism known as calcimimetics, which reduce parathyroid hormone (PTH) synthesis and secretion by increasing the sensitivity of the parathyroid calcium-sensing receptor (CaR) to extracellular calcium.
A10554 SALE

Manidipine 2HCl

-
Manidipine 2HCl is a HCl salt form of Manidipine which is a calcium channel blocker for Ca2+ current with IC50 of 2.6 nM.
A10068 SALE

Amlodipine

L-type calcium channel blocker
Amlodipin is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease.
A10069

Amlodipine besylate (Norvasc)

L-type calcium channel blocker
Amlodipine-besylate is L-type calcium channel blocker that displays antihypertensive properties. It inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease.
A10215 SALE

Cilnidipine

Calcium channel blocker
Cilnidipine is a dual blocker of L-type voltage-gated calcium channels in vascular smooth muscle and N-type calcium channels in sympathetic nerve terminals that supply.
A10487 SALE

Isradipine

calcium channel blocker
Isradipine is a calcium channel blocker of the dihydropyridine class.
A11219

Azelnidipine

calcium channel blocker
Azelnidipine is a calcium blocker that attenuates liver fibrosis and may increase antioxidant defence. that attenuates liver fibrosis and may increase antioxidant defence.
A11729

Lacidipine

-
Lacidipine is a calcium channel blocker
A11730

Benidipine hydrochloride

-
Benidipine hydrochloride is a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus.
A11731

Nilvadipine (ARC029)

calcium channel blocker
Nilvadipine is a calcium channel blocker (CCB) used for the treatment of hypertension and chronic major cerebral artery occlusion
A11746 SALE

Clevidipine

Calcium channel blocker
Clevidipine is a dihydropyridine calcium channel blocker indicated for the reduction of blood pressure when oral therapy is not feasible or not desirable.
A10309

Diethylstilbestrol

-
Diethylstilbestrol is a synthetic nonsteroidal estrogen that was first synthesized in 1938. It is also classified as an endocrine disruptor.
A10311 SALE

Diltiazem HCl

-
Diltiazem is a nondihydropyridine (non-DHP) member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia.

产品 1 到 50 共 228个

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