Membrane Transporters/Ion Channels

产品 1 到 50 共 318个

每页
页面:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

设置升序顺序
  1. Brefeldin A

    Catalog No. A11156
    Quick View
    Protein translocation 抑制剂
    Brefeldin A阻断ADP-核糖基化因子与高尔基体的结合并抑制GDP-GTP交换。 了解更多
  2. PF 3716556

    Catalog No. A11408
    Quick View
    ATPase 拮抗剂
    PF 3716556是H+,K+-ATPase酶抑制剂(在人类重组离子渗漏试验中PIC50 = 6)。 了解更多
  3. Sodium orthovanadate

    Catalog No. A10854
    Quick View
    protein tyrosine phosphatases inhibitor
    Sodium orthovanadate是化合物Na3VO4。 它是蛋白质酪氨酸磷酸酶,碱性磷酸酶和许多ATPase的抑制剂,很可能充当磷酸盐类似物。 了解更多
  4. Artemisinin

    Catalog No. A10086
    Quick View
    Artemisinin及其衍生物是一类药物,在所有当前针对恶性疟原虫疟疾的药物中具有最快的作用。 了解更多
  5. Ciclopirox

    Catalog No. A10213
    Quick View
    Ciclopirox是一种合成的抗真菌药物。它可以抑制酵母糠醛马拉丝霉的生长,并通过中断Na+K+ ATPase来抑制膜转移系统,从而发挥作用。 了解更多
  6. Pantoprazole (Protonix)

    Catalog No. A11696
    Quick View
    Pantoprazole是一种质子泵抑制剂药物,可抑制胃酸分泌。 了解更多
  7. Bafilomycin A1

    Catalog No. A11961
    ATPase 抑制剂
    Bafilomycin A1通过抑制大鼠肝癌细胞系H-4-II-E细胞中自噬体和溶酶体之间的融合来防止自噬泡的成熟。 了解更多
  8. Bufalin

    Catalog No. A12022
    Quick View
    Bufalin是蟾酥中的有效活性成分,为有效的 Na+/K+-ATPase 抑制剂,可与其基 α1, α2 和 α3 结合,Kd 值分别为 42.5,45 和 40 nM。具有抗肿瘤活性。 了解更多
  9. Resibufogenin

    Catalog No. A12023
    Quick View
    Resibufogenin是一种特异性na+/k+-ATP酶抑制剂。 了解更多
  10. Bufotalin

    Catalog No. A12024
    Quick View
    Bufotalin是一种比其他蟾毒二烯内酯更弱的na+/k+-ATP酶抑制剂。强效免疫抑制剂。 了解更多
  11. Cinobufagin

    Catalog No. A12032
    Quick View
    Cinobufagin是一种特异性na+/k+-ATP酶抑制剂。大约和哇巴因一样活跃。 了解更多
  12. Ouabain

    Catalog No. A12755
    a-K-ATPase 抑制剂
    Ouabain是一种选择性的Na+,K+-ATPase抑制剂。 了解更多
  13. Oligomycin A

    Catalog No. A10669
    Quick View
    ATPase 抑制剂
    Oligomycin A是线粒体ATPase抑制剂。寡霉素A抑制与细胞膜结合的ATP5(线粒体ATP酶,F1F0)。 了解更多
  14. Omeprazole

    Catalog No. A10672
    Quick View
    ATPase 抑制剂
    Omeprazole是一种可透过细胞的选择性质子泵抑制剂。 了解更多
  15. PST-2744 (Istaroxime)

    Catalog No. A13041
    PST-2744 (Istaroxime)是一种正性肌力药物,通过抑制钠/钾腺苷三磷酸酶(Na+/K+ ATPase)介导其作用。 了解更多
  16. Rostafuroxin (PST-2238)

    Catalog No. A13283
    Quick View
    Na+/K+ ATPase modulator
    Rostafuroxin (PST-2238)是一种哇巴因抑制剂,可对抗特定形式的高血压。 了解更多
  17. (-)-Blebbistcitin

    Catalog No. A13647
    Quick View
    myosin II 抑制剂
    (-)-Blebbistcitin是有效且选择性的 myosin II 抑制剂,IC50 范围为0.5至5 μM。 了解更多
  18. BTB06584

    Catalog No. A14308
    Quick View
    F1 Fo-ATPase 抑制剂
    BTB06584是线粒体F1 Fo-ATPase的IF1依赖性选择性抑制剂。 了解更多
  19. Melittin

    Catalog No. A13912
    Quick View
    Na+/K+ ATPase 抑制剂
    Melittin是一种Na+/K+ ATPase抑制剂。它抑制Gs并刺激Gi活性。它抑制蛋白激酶C和依赖cAMP的蛋白激酶。 了解更多
  20. Oligomycin

    Catalog No. A14000
    ATP synthase 抑制剂
    Oligomycin是一种大环内酯类化合物,可作为线粒体ATP合酶的特异性抑制剂并阻止氧化磷酸化作用。 了解更多
  21. Cyclopiazonic Acid

    Catalog No. A14002
    Quick View
    SERCA 抑制剂
    Cyclopiazonic acid是SERCA(内质网Ca2+ -ATPase)的抑制剂,可诱导细胞内储存的Ca2+释放,而不会增加IP3水平。 了解更多
  22. Thapsigargin

    Catalog No. A14007
    SERCA ATPase 抑制剂
    Thapsigargin是在Thapsia garganica的根中发现的一种细胞可渗透的倍半萜烯内酯。它是肿瘤的启动子,可通过抑制肌浆/内质网Ca2+ -ATPase(SERCA,IC50 = 30 nM)诱导细胞内储存的Ca2+释放,而不会水解肌醇磷脂。 了解更多
  23. Glucagon (19-29), human

    Catalog No. A14875
    Quick View
    Ca 2+ /Mg 2+ -ATPase 抑制剂
    Glucagon (19-29), human是有效的Ca2+/Mg2+ -ATPase抑制剂。 了解更多
  24. PTC124 (Ataluren)

    Catalog No. A10758
    Quick View
    CFTR 抑制剂
    PTC124也称为Ataluren,是CFTR-G542X无意义等位基因抑制剂。 了解更多
  25. VX-770 (Ivacaftor)

    Catalog No. A10985
    Quick View
    CFTR activator
    VX-770 (Ivacaftor)被称为CFTR增强剂,靶向作用于G551D-CFTR和F508del-CFTR,在fisher大鼠甲状腺细胞中EC50分别为100 nM和25 nM。 了解更多
  26. VX-809 (Lumacaftor)

    Catalog No. A10986
    Quick View
    CFTR modulator
    VX-809 (Lumacaftor)是用于治疗囊性纤维化(CF)的第二种口服研究候选化合物,通过促进突变型CFTR(F508del-CFTR)的成熟,从而纠正囊性纤维症中常见的CFTR突变,在fisher大鼠甲状腺细胞中EC50为0.1 μM。 了解更多
  27. VX-661

    Catalog No. A12519
    Quick View
    CFTR corrector
    VX-661是另一种正在开发中的用于治疗囊性纤维化的囊性纤维化跨膜电导调节器(CFTR)校正器。 了解更多
  28. Glyburide

    Catalog No. A10433
    Quick View
    K+ channel and CFTR Cl- channel blocker
    Glyburide (Glibenclamide) 是一种抗糖尿病化合物,是一类磺脲类药物。 了解更多
  29. IOWH032

    Catalog No. A13511
    Quick View
    CFTR 抑制剂
    IOWH032是CFTR抑制剂。 了解更多
  30. CFTR-Inhibitor-II

    Catalog No. A13723
    Quick View
    CFTR 抑制剂
    CFTR inhibitor II,也称为GlyH-101,是一种甘氨酸酰肼,可选择性和可逆地阻断CFTR通道(Ki = 4.3 uM)。 了解更多
  31. PPQ-102

    Catalog No. A13000
    Quick View
    CFTR chloride channel 抑制剂
    PPQ-102是一种化合物,其靶向cftr的胞内核苷酸结合结构域,并以电压依赖性和可逆的方式抑制cftr介导的氯离子电流。 了解更多
  32. Oridonin (Isodonol)

    Catalog No. A10675
    Quick View
    CFTR 抑制剂
    Oridonin (Isodonol)是一种从鼠李木中分离出来的Entkaurane二萜类化合物,是一种重要的传统中草药。 了解更多
  33. CFTRinh-172

    Catalog No. A12897
    Quick View
    CFTR 抑制剂
    CFTRinh-172是电压无关的选择性CFTR抑制剂。在2分钟内可逆地抑制CFTR短路电流的 Ki 值为300 nM。 了解更多
  34. KM 11060

    Catalog No. A15843
    Quick View
    F508del-CFTR trafficking corrector
    KM 11060纠正了F508del-CFTR的运输,增加了质膜上功能性CFTR的量(?75%)并抑制了PDE5的活性。 了解更多
  35. PG 01

    Catalog No. A18315
    Quick View
    CFTR potentiator
    PG 01 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator. PG 01 is effective on G970R although with a significant decrease in potency relative to E193K and δF508. 了解更多
  36. CFTR corrector 2

    Catalog No. A18528
    Quick View
    CFTR corrector
    CFTR corrector 2 is a cystic fibrosis transmembrane conductance corrector (CFTR), extracted from patent US20140274933. 了解更多
  37. GLPG2451

    Catalog No. A18919
    Quick View
    CFTR potentiator
    GLPG2451 is a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator, which effectively potentiates low temperature rescued F508del CFTR with an EC50 of 11.1 nM. 了解更多
  38. Ivacaftor benzenesulfonate

    Catalog No. A15132
    Quick View
    CFTR potentiator
    Ivacaftor benzenesulfonate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. 了解更多
  39. Ivacaftor hydrate

    Catalog No. A15133
    Quick View
    CFTR potentiator
    Ivacaftor hydrate is an orally bioavailable CFTR potentiator, used for cystic fibrosis treatment. 了解更多
  40. Caldaret

    Catalog No. A13148
    Quick View
    intracellular Ca2+ handling modulator
    Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition. 了解更多
  41. ABT-639 hydrochloride

    Catalog No. A12571
    Quick View
    T-type Ca2+ channel blocker
    ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker. 了解更多
  42. (S)-(-)-Bay-K-8644

    Catalog No. A21164
    Quick View
    L-type Ca2+ channel agonist
    (S)-(-)-Bay-K-8644 is an agonist of L-type Ca2+ channel. (S)-(-)-Bay-K-8644 activates Ba2+ currents (IBa) (EC50=32 nM). 了解更多
  43. TTA-Q6

    Catalog No. A21360
    Quick View
    T-type Ca2+ channel antagonist
    TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease. 了解更多
  44. TTA-Q6(isomer)

    Catalog No. A21724
    Quick View
    T-type Ca2+ channel antagonist
    TTA-Q6(isomer) is an isomer of TTA-Q6. TTA-Q6 is a selective T-type Ca2+ channel antagonist. 了解更多
  45. JTV-519 free base

    Catalog No. A21846
    Quick View
    Ca2+-dependent blocker
    TV-519 free base (K201 free base) is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle. Antiarrhythmic and cardioprotective properties. 了解更多
  46. GV-58

    Catalog No. A21966
    Quick View
    N- and P/Q-type Ca2+ channels agonist
    GV-58 is a potent, selective N- and P/Q-type Ca2+ channels agonist with EC50 of 7.21/8.81 uM for N-type/P-Q-type Ca2+ channel; 20-fold less potent CDK inhibitor activity. 了解更多
  47. Tetrandrine (Fanchinine)

    Catalog No. A10921
    Quick View
    Calcium Channel 抑制剂
    Tetrandrine (Fanchinine)是一种钙通道阻滞剂。粉防己碱具有抗炎和抗纤维化作用,使粉防己碱及其相关化合物潜在地用于治疗肺矽肺,肝硬化和类风湿性关节炎。 了解更多
  48. Astragaloside A

    Catalog No. A11405
    Quick View
    Ca2+ signaling modulator
    Astragaloside A是缺氧条件下人脐静脉内皮细胞HIF-1α和通过PI3K/Akt途径血管生成的一种新型调节因子。 了解更多
  49. CK-1827452 (Omecamtiv mecarbil)

    Catalog No. A11206
    Quick View
    Myosin activator
    CK-1827452 (Omecamtiv mecarbil)是选择性的心脏特异性肌球蛋白激活剂。 了解更多
  50. Manidipine 2HCl

    Catalog No. A10554
    Quick View
    Manidipine dihydrochloride是Manidipine的HCl盐形式,Manidipine是Ca2+电流的钙通道阻滞剂,IC50为2.6 nM。 了解更多

产品 1 到 50 共 318个

每页
页面:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

设置升序顺序
Rewards