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2-Methoxyestradiol

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Apoptotic, antiproliferative and antiangiogenic agent

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产品目录号: A10012

库存状态:中国现货中国现货

产品名 目录号 价格 数量
2-Methoxyestradiol 10mg A10012-10
¥ 400.00
2-Methoxyestradiol 50mg A10012-50
¥ 1,000.00
2-Methoxyestradiol 100mg A10012-100
¥ 1,700.00
2-Methoxyestradiol 200mg A10012-200
¥ 3,000.00
2-Methoxyestradiol 10mM * 1mL in DMSO A10012-10mM-D
¥ 710.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.

2-Methoxyestradiol

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Chemical Information

目录号 A10012
Mechanism of action
分子量 302.4
化学分子式 C19H26O3
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 362-07-2
Synonyms 2-ME2
SMILES code [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C(OC)=C3
化学名称 (17β)-2-Methoxyestra-1,3,5(10)-trien e-3,17-diol

生物活性

Description
2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.
Targets
HIF-2α (Rat aortic smooth muscle A-10 cells) Microtubule Associated (Cell-free assay) HIF-1α (MDA-MB-231 cells)

溶解性

Solubility (25°C)* In vitro DMSO 60 mg/mL (198.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.07 mL 165.34 mL 330.69mL
0.5 mM 6.61 mL 33.07 mL 66.14 mL
1 mM 3.31 mL 16.53 mL 33.07 mL
5 mM 0.66 mL 3.31 mL 6.61 mL

*The above data is based on the productmolecular weight 302.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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