2-Methoxyestradiol

目录号: A10012

Apoptotic, antiproliferative and antiangiogenic agent

2-Methoxyestradiol Chemical Structure

CAS NO. 362-07-2

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.

库存: 现货

规格 价格 数量
10 mg
¥ 400.00
50 mg
¥ 1,000.00
100 mg
¥ 1,700.00
200 mg
¥ 3,000.00
10mM * 1mL in DMSO
¥ 710.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

2-Methoxyestradiol is an apoptotic, antiproliferative and antiangiogenic agent. Induces p53-induced apoptosis via two pathways: activation of p38 and NF-κB; and activation of JNK and AP-1 leading to Bcl-2 phosphorylation.
Targets
HIF-2α (Rat aortic smooth muscle A-10 cells) Microtubule Associated (Cell-free assay) HIF-1α (MDA-MB-231 cells)
In vitro DMSO 60 mg/mL (198.4 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 33.07 mL 165.34 mL 330.69 mL
0.5 mM 6.61 mL 33.07 mL 66.14 mL
1 mM 3.31 mL 16.53 mL 33.07 mL
5 mM 0.66 mL 3.31 mL 6.61 mL

*The above data is based on the productmolecular weight 302.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10012
MECHANISM OF ACTION
M. Wt 302.4
Formula C19H26O3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 362-07-2
Synonyms 2-ME2
SMILES [H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])C3=C(CC[C@@]21[H])C=C(O)C(OC)=C3

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