Domatinostat (4SC-202)
目录号: A14354
HDAC 抑制剂
4SC-202 是一种口服生物可利用的苯甲酰胺类化合物,它是人类 I类组蛋白去乙酰化酶(HDACs)同工酶1、2和3的抑制剂,具有潜在的抗肿瘤活性。
Discription | 4SC-202 is an orally bioavailable benzamide and inhibitor of human class I histone deacetylases (HDACs) isoenzymes 1, 2 and 3, with potential antineoplastic activity. | ||
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Targets |
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目录号 | A14354 |
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分子式 | C23H21N5O3S |
分子量 | 447.51 |
CAS号 | 910462-43-0 |
SMILES | CN1C=C(C=N1)C2=CC=C(C=C2)S(=O)(=O)N3C=CC(=C3)/C=C/C(=O)NC4=CC=CC=C4N |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 77 mg/mL (172.06 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 22.35 mL | 111.73 mL | 223.46 mL |
0.5 mM | 4.47 mL | 22.35 mL | 44.69 mL |
1 mM | 2.23 mL | 11.17 mL | 22.35 mL |
5 mM | 0.45 mL | 2.23 mL | 4.47 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2