A-1155463

Name: A-1155463
SKU: A16112
Price: 210 CNY
Rating: 5 (3 reviews)

目录号: A16112

BCL-XL 抑制剂

3 篇发表文献

A-1155463 是一种高效且选择性的 BCL-XL 抑制剂，A-1155463 对 BCL-XL 的结合亲和力达到皮克摩尔级别（Ki = <0.01 nM），对 BCL-2 的结合亲和力弱 1000 倍以上（Ki = 80 nM），以及对相关蛋白 BCL-W（Ki = 19 nM）和 MCL-1（Ki > 440 nM）的结合也显著较弱。

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Grouped product items
规格	价格	库存
1mg	¥210.00	现货
2mg	¥315.00	现货
5mg	¥560.00	现货
10mg	¥980.00	现货
25mg	¥1,890.00	现货
50mg	¥3,605.00	现货
100mg	¥6,930.00	现货
*10mM 1mL in DMSO**	¥875.00	现货
更大包装	更多折扣

大包装询价

Notify me when the price drops

全国免运费, 顺丰次日达

重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用A-1155463发表的3篇文献

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

Daniel F R Boehmer, .et al. , Sci Immunol, 2021, Jul 16;6(61) PMID: 34272227

Chauhan D, .et al. , Cell Rep, 2018, Nov 27;25(9):2354-2368.e5 PMID: 30485805

生物活性

Discription

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A16112
分子式	C35H32FN5O4S2
分子量	669.79
CAS号	1235034-55-5
SMILES	O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O
其他名称	A 1155463, A1155463
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	78 mg/mL (116.45 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+30% PEG 300+2% Tween 80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.93 mL	74.65 mL	149.3 mL
0.5 mM	2.99 mL	14.93 mL	29.86 mL
1 mM	1.49 mL	7.47 mL	14.93 mL
5 mM	0.3 mL	1.49 mL	2.99 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords: 购买 A-1155463 | A-1155463 供应商 | A-1155463 花费 | A-1155463 生产商 | 订购 A-1155463 | A-1155463 代理商 | 购买 1235034-55-5 | 1235034-55-5 供应商 | 1235034-55-5 花费 | 1235034-55-5 生产商 | 订购 1235034-55-5 | 1235034-55-5 代理商