A-1155463

目录号: A16112

BCL-XL inhibitor

A-1155463 Chemical Structure

CAS NO. 1235034-55-5

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)

库存: 现货

规格 价格 数量
5 mg
¥ 1,200.00
10 mg
¥ 2,000.00
50 mg
¥ 8,000.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

详情

A-1155463 is a highly potent and selective BCL-XL inhibitor, A-1155463 shows picomolar binding affinity to BCL-XL (Ki = <0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki = 80 nM) and related proteins BCL-W (Ki = 19 nM) and MCL-1 (Ki > 440 nM)
Targets
BCL-XL Bcl-w Bcl-2 Mcl-1
440 nM(Ki)
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.93 mL 74.65 mL 149.3 mL
0.5 mM 2.99 mL 14.93 mL 29.86 mL
1 mM 1.49 mL 7.47 mL 14.93 mL
5 mM 0.3 mL 1.49 mL 2.99 mL

*The above data is based on the productmolecular weight 669.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A16112
MECHANISM OF ACTION Inhibitor
M. Wt 669.79
Formula C35H32FN5O4S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1235034-55-5
Synonyms A 1155463, A1155463
SMILES O=C(C1=C(CCCOC2=CC=C(C#CCN(C)C)C=C2F)SC(N3CC4=C(C=CC=C4C(NC5=NC6=CC=CC=C6S5)=O)CC3)=N1)O

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