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A-485是p300/CBP的强效选择性HAT抑制剂，在p300 TR-FRET分析中的IC50为10 nM，在CBP TR-FRET分析中的IC50为3 nM，选择性是紧密相关的HAT的1000倍以上。
| In vitro | DMSO | 89 mg/mL (165.9 mM) | |
| Water | Insoluble | ||
| Ethanol | 89 mg/mL (165.9 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.64 mL | 93.2 mL | 186.4 mL |
| 0.5 mM | 3.73 mL | 18.64 mL | 37.28 mL |
| 1 mM | 1.86 mL | 9.32 mL | 18.64 mL |
| 5 mM | 0.37 mL | 1.86 mL | 3.73 mL |
*The above data is based on the productmolecular weight 536.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16830 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 536.48 |
| Formula | C25H24F4N4O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1889279-16-6 |
| Synonyms | A 485, A485 |
| SMILES | O=C(N1CC(N([C@H](C(F)(F)F)C)CC2=CC=C(F)C=C2)=O)[C@@]3(OC1=O)CCC4=CC(NC(NC)=O)=CC=C43 |
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