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A-674563

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Akt 抑制剂

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产品目录号: A11034

库存状态:中国现货中国现货

产品名 目录号 价格 数量
A-674563 5mg A11034-5
¥ 1,400.00
A-674563 10mg A11034-10
¥ 2,200.00
A-674563 25mg A11034-25
¥ 4,000.00
A-674563 50mg A11034-50
¥ 6,500.00
A-674563 10mM * 1mL in DMSO A11034-10mM-D
¥ 1,590.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.

A-674563

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 A-674563 发表的文献 (3)
  • Kobayashi T, .et al. A-674563 increases chondrocyte marker expression in cultured chondrocytes by inhibiting Sox9 degradation, Biochem Biophys Res Commun, 2018, Jan 1;495(1):1468-1475 PMID: 29196261
  • Lin Xu, .et al. Concurrent targeting Akt and sphingosine kinase 1 by A-674563 in acute myeloid leukemia cells, Biochem Biophys Res Commun, 2016, Apr 15;472(4):662-8 PMID: 26920060
  • Zou Y, .et al. Pre-clinical assessment of A-674563 as an anti-melanoma agent, Biochem Biophys Res Commun, 2016, Aug 12;477(1):1-8 PMID: 26970307

Chemical Information

目录号 A11034
Mechanism of action Inhibitor
分子量 358.4
化学分子式 C22H22N4O
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 552325-73-2
Synonyms A674563
SMILES code CC1=C2C=C(C=CC2=NN1)C3=CC(=CN=C3)OC[C@H](CC4=CC=CC=C4)N
化学名称 (alphaS)-alpha-[[[5-(3-Methyl-1H-indazol-5-yl)-3-pyridinyl]oxy]methyl]benzeneethanamine

生物活性

Description
A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
Targets
Target Value
Akt1ki: 11nM
PKAki: 16nM
CDK2ki: 46nM
GSK-3βki: 110nM
ERK2ki: 260nM
PKCδki: 360nM
RSK2ki: 580nM
MAPK-AP2ki: 1.1μM
PKCγki: 1.2μM
FLT1ki: >2.2μM
Chk1ki: 2.6μM
KDRki: >3.7μM
CK2ki: 5.4μM
c-Kitki: >5.8μM
Srcki: 13μM
PDK-1ki: >20μM

溶解性

Solubility (25°C) * In vitro DMSO 72 mg/mL (200.87 mM)
Water 72 mg/mL (200.87 mM)
Ethanol 18 mg/mL (50.21 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.9 mL 139.51 mL 279.02mL
0.5 mM 5.58 mL 27.9 mL 55.8 mL
1 mM 2.79 mL 13.95 mL 27.9 mL
5 mM 0.56 mL 2.79 mL 5.58 mL

*The above data is based on the productmolecular weight 358.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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