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A-769662

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AMPK activator

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产品目录号: A11071

库存状态:中国现货中国现货

产品名 目录号 价格 数量
A-769662 5mg A11071-5
¥ 400.00
A-769662 10mg A11071-10
¥ 650.00
A-769662 50mg A11071-50
¥ 2,600.00
A-769662 100mg A11071-100
¥ 4,800.00
A-769662 10mM * 1mL in DMSO A11071-10mM-D
¥ 700.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

A-769662 is a new activator of AMP-activated protein kinase (AMPK).

A-769662

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 A-769662 发表的文献 (2)
  • Kikuchi H, .et al. Failure to sense energy depletion may be a novel therapeutic target in chronic kidney disease, Kidney Int, 2018, Nov 13. pii: S0085-2538(18)30635-5 PMID: 30455054
  • Schneider H, .et al. AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle, Hypertension, 2015, Jul;66(1):108-16 PMID: 26034200

Chemical Information

目录号 A11071
Mechanism of action Activator
分子量 360.4
化学分子式 C20H12N2O3S
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 844499-71-4
Synonyms A769662
SMILES code C1=CC=C(C(=C1)C2=CC=C(C=C2)C3=CSC4=C3C(=C(C(=O)N4)C#N)O)O
化学名称 6,7-Dihydro-4-hydroxy-3-(2'-hydroxy[1,1'-biphenyl]-4-yl)-6-oxo-thieno[2,3-b]pyridine-5-carbonitrile

生物活性

Description
A-769662 is a new activator of AMP-activated protein kinase (AMPK).
Targets
AMPK (Cell-free assay) Fatty acid synthesis (Cell-free assay)
0.8 μM(EC50)3.2 μM

溶解性

Solubility (25°C) * In vitro DMSO 72 mg/mL (199.78 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 27.75 mL 138.73 mL 277.47mL
0.5 mM 5.55 mL 27.75 mL 55.49 mL
1 mM 2.77 mL 13.87 mL 27.75 mL
5 mM 0.55 mL 2.77 mL 5.55 mL

*The above data is based on the productmolecular weight 360.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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