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A 922500

DGAT-1 抑制剂

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产品目录号: A11199

库存状态:中国现货中国现货

产品名 目录号 价格 数量
A 922500 5mg A11199-5
¥ 800.00
A 922500 10mg A11199-10
¥ 1,400.00
A 922500 50mg A11199-50
¥ 4,000.00
A 922500 100mg A11199-100
¥ 7,000.00
A 922500 10mM * 1mL in DMSO A11199-10mM-D
¥ 1,280.00

产品仅用于研究,不针对患者销售,望谅解.

产品简介

A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively).

A 922500

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顾客使用 Adooq 产品发表的高质量科研文献
Adooq 顾客使用 A 922500 发表的文献 (1)
  • SIFEI HAN, .et al. Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug, J Pharm Sci, 2016, Feb;105(2):786-796 PMID: 6540595

Chemical Information

目录号 A11199
Mechanism of action Inhibitor
分子量 428.48
化学分子式 C26H24N2O4
Solubility DMSO
纯度 >98%
储存方式 at -20°C 2 years
CAS No. 959122-11-3
Synonyms DGAT-1 Inhibitor 4a, A-922500, A922500
SMILES code C1C[C@H]([C@@H](C1)C(=O)O)C(=O)C2=CC=C(C=C2)C3=CC=C(C=C3)NC(=O)NC4=CC=CC=C4
化学名称 (1R,2R)-2-[[4'-[[Phenylamino)carbony l]amino] [1,1'-biphenyl]-4-yl]carbonyl]cyclopentanecarboxyli c acid

生物活性

Description

A 922500 is a diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively).

Targets
human DGAT-1 mouse DGAT-1 DGAT-2
7 nM24 nM53 μM

溶解性

Solubility (25°C) * In vitro DMSO 86 mg/mL (200.7 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 15% Captisol 20 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.34 mL 116.69 mL 233.38mL
0.5 mM 4.67 mL 23.34 mL 46.68 mL
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL

*The above data is based on the productmolecular weight 428.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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