A1874

目录号: A18735

BRD4-degrading PROTAC

A1874

A1874 Chemical Structure

CAS NO. 2064292-12-0

A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.

库存: 现货

规格 价格 数量
1 mg
¥ 1,800.00
5 mg
¥ 6,200.00
10 mg
¥ 8,800.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation.
In vitro DMSO 92 mg/mL (78.38 mM)
Water Insoluble
Ethanol 92 mg/mL (78.38 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 8.52 mL 42.6 mL 85.21 mL
0.5 mM 1.7 mL 8.52 mL 17.04 mL
1 mM 0.85 mL 4.26 mL 8.52 mL
5 mM 0.17 mL 0.85 mL 1.7 mL

*The above data is based on the productmolecular weight 1173.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A18735
M. Wt 1173.6
Formula C58H62Cl3F2N9O7S
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 2064292-12-0
Synonyms A1874, A-1874
SMILES O=C([C@@H]1N[C@@H](CC(C)(C)C)[C@](C#N)(C2=CC=C(Cl)C=C2F)[C@H]1C3=CC=CC(Cl)=C3F)NC4=CC=C(C(NCCOCCOCCOCCNC(C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5)=O)=O)C=C4

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