A1874
目录号: A18735
BRD4-degrading PROTAC
A1874 是一种基于 nutlin 的、能够降解 BRD4 的 PROTAC，其 DC50 为 32 nM（在细胞中诱导 BRD4 降解）。在抑制多种癌细胞系的增殖方面表现出效果。
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生物活性
| Discription | A1874 is a nutlin-based and BRD4-degrading PROTAC with a DC50 of 32 nM (induce BRD4 degradation in cells). Effective in inhibiting many cancer cell lines proliferation. | ||
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产品信息
| 目录号 | A18735 |
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| 分子式 | C58H62Cl3F2N9O7S |
| 分子量 | 1173.6 |
| CAS号 | 2064292-12-0 |
| SMILES | CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCCNC(=O)C4=CC(=C(C=C4)NC(=O)[C@H]5[C@@H]([C@@]([C@@H](N5)CC(C)(C)C)(C#N)C6=C(C=C(C=C6)Cl)F)C7=C(C(=CC=C7)Cl)F)OC)C8=CC=C(C=C8)Cl)C |
| 其他名称 | A1874, A-1874 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 92 mg/mL (78.38 mM) | |
| Water | Insoluble | ||
| Ethanol | 92 mg/mL (78.38 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 8.52 mL | 42.6 mL | 85.21 mL |
| 0.5 mM | 1.7 mL | 8.52 mL | 17.04 mL |
| 1 mM | 0.85 mL | 4.26 mL | 8.52 mL |
| 5 mM | 0.17 mL | 0.85 mL | 1.7 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 2064292-12-0 | 2064292-12-0 供应商 | 2064292-12-0 花费 | 2064292-12-0 生产商 | 订购 2064292-12-0 | 2064292-12-0 代理商