Opaganib (ABC294640)
目录号: A12614
SphK2 抑制剂
ABC294640 是一种口服可用的芳基亚当坦化合物,是鞘氨醇激酶-2(SK2)的选择性抑制剂,具有潜在的抗肿瘤活性。
| Discription | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. | ||
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| 目录号 | A12614 |
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| 分子式 | C23H25ClN2O |
| 分子量 | 380.16554 |
| CAS号 | 915385-81-8 |
| SMILES | C1[C@H]2CC3(CC1CC(C2)(C3)C(=O)NCC4=CC=NC=C4)C5=CC=C(C=C5)Cl |
| 其他名称 | ABC-294640, ABC 294640 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | Warmed: 75 mg/mL (196.89 mM) | |
| Water | Insoluble | ||
| Ethanol | 28 mg/mL (73.5 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.3 mL | 131.52 mL | 263.04 mL |
| 0.5 mM | 5.26 mL | 26.3 mL | 52.61 mL |
| 1 mM | 2.63 mL | 13.15 mL | 26.3 mL |
| 5 mM | 0.53 mL | 2.63 mL | 5.26 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2