Abciximab (C7E3) is a chimeric monoclonal antibody fragment derived from both mouse and human sources, functioning as an inhibitor of glycoprotein (GP) IIb/IIIa. This agent effectively blocks platelet aggregation and leukocyte adhesion, mechanisms crucial for thrombosis and inflammatory responses, respectively. It achieves its therapeutic effects by targeting and binding to the GP IIb/IIIa receptor, as well as to vitronectin and Mac-1 receptors. This specificity makes Abciximab an essential tool in the study of platelet aggregation pathways and the development of anti-thrombotic therapies.
Abciximab (C7E3) is a chimeric monoclonal antibody fragment derived from both mouse and human sources, functioning as an inhibitor of glycoprotein (GP) IIb/IIIa. This agent effectively blocks platelet aggregation and leukocyte adhesion, mechanisms crucial for thrombosis and inflammatory responses, respectively. It achieves its therapeutic effects by targeting and binding to the GP IIb/IIIa receptor, as well as to vitronectin and Mac-1 receptors. This specificity makes Abciximab an essential tool in the study of platelet aggregation pathways and the development of anti-thrombotic therapies.
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