Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody engineered to bind with high affinity to the catalytic structural domain of Factor XI (FXI). This interaction effectively locks FXI in its zymogen conformation, inhibiting its activation by Factor XIIa (FXIIa) or thrombin. Due to its specific mechanism of action, Abelacimab is an excellent tool for research into thromboembolic diseases, providing insights into the regulation of coagulation pathways and the development of antithrombotic therapies.
Abelacimab (MAA868) is a fully human IgG1 monoclonal antibody engineered to bind with high affinity to the catalytic structural domain of Factor XI (FXI). This interaction effectively locks FXI in its zymogen conformation, inhibiting its activation by Factor XIIa (FXIIa) or thrombin. Due to its specific mechanism of action, Abelacimab is an excellent tool for research into thromboembolic diseases, providing insights into the regulation of coagulation pathways and the development of antithrombotic therapies.
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